4 documents found, page 1 of 1
Hematopoietic progenitor cell mobilization for autologous transplantation - a l...
Salvino,Marco Aurélio; Ruiz,JeffersonABSTRACT The use of high-dose chemotherapy with autologous support of hematopoietic progenitor cells is an effective strategy to treat various hematologic neoplasms, such as non-Hodgkin lymphomas and multiple myeloma. Mobilized peripheral blood progenitor cells are the main source of support for autologous transplants, and collection of an adequate number of hematopoietic progenitor cells is a critical step in ...
Allogeneic bone marrow transplantation for severe aplastic anemia patients with...
Medeiros,Carlos R. de; Coutinho,Elenaide; Carmes,Eliane R.; Bitencourt,Marco A.; Ruiz,Jefferson; Bonfim,Carmen S.; Funke,Vaneusa M.; Setubal,Daniela C.Hematopoietic progenitor cell transplantation from HLA-identical sibling donors cures 70-90% of Severe Aplastic Anemia (sAA) patients. Older age, heavy exposure to transfusions, immunosuppression treatment (IST) with a long interval from diagnosis to transplant and infection at procedure are associated with poor outcomes. We transplanted 18 patients with sAA and at least one risk factor (RF) for poor prognosis ...
O tratamento da Leucemia Mielóide Crônica com mesilato de imatinibe
Funke,Vaneuza M.; Setubal,Daniela C.; Ruiz,Jefferson; Azambuja,Ana Paula; Lima,Denise H.; Kojo,Terezinha K.; Pasquini,RicardoO mesilato de imatinibe é atualmente o tratamento de escolha para pacientes com Leucemia mielóide Crônica (LMC) recém-diagnosticados. Desde os primeiros estudos clínicos em 1998 até o estudo IRIS, que comparou o uso em primeira linha de imatinibe com interferon + ara-C, esta droga vem se consolidando em segurança e eficácia. Ainda há, entretanto questionamentos sobre a melhor dose inicial, a identificação dos p...
Therapy of chronic myeloid leukemia with imatinib mesylate in Brazil: a study o...
Funke,Vaneuza A. M.; Medeiro,Carlos R.; Lima,Denise H.; Setúbal,Daniela C.; Bitencourt,Marco A.; Bonfim,Carmem M.; Ruiz,Jefferson; Zanis Neto,JoséChronic Myeloid Leukemia (CML) is a clonal disease characterized by balanced translocation between chromosomes 9 and 22 (Philadelphia chromosome). The resulting BCR-ABL gene has tyrosine kinase activity which stimulates cellular growth. Imatinib mesylate is a potent and specific inhibitor of all ABL related kinases. Ninety-eight CML patients were treated with imatinib mesylate from October 2000 to January 2003....