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Revisiting mutational resistance to ampicillin and cefotaxime in Haemophilus in...

Diricks, Margo; Petersen, Sabine; Bartels, Lennart; Lâm, Thiên-Trí; Claus, Heike; Bajanca-Lavado, Maria Paula; Hauswaldt, Susanne; Stolze, Ricardo

Background: Haemophilus influenzae is an opportunistic bacterial pathogen that can cause severe respiratory tract and invasive infections. The emergence of β-lactamase-negative ampicillin-resistant (BLNAR) strains and unclear correlations between genotypic (i.e., gBLNAR) and phenotypic resistance are challenging empirical treatments and patient management. Thus, we sought to revisit molecular resistance mechani...


Bacterial etiology of community-acquired pneumonia in immunocompetent hospitali...

Carugati, Manuela; Aliberti, S.; Sotgiu, G.; Blasi, F.; Gori, A.; Menendez, R.; Encheva, M.; Gallego, M.; Leuschner, P.; Ruiz-Buitrago, S.

An accurate knowledge of the epidemiology of community-acquired pneumonia (CAP) is key for selecting appropriate antimicrobial treatments. Very few etiological studies assessed the appropriateness of empiric guideline recommendations at a multinational level. This study aims at the following: (i) describing the bacterial etiologic distribution of CAP and (ii) assessing the appropriateness of the empirical treat...


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