3 documents found, page 1 of 1
Preserving cognitive function in patients with Alzheimer's disease: The Alzheim...
Liu, Jie; Van Beusekom, Heleen; Bu, Xian‐Le; Chen, Gong; Rosado de Castro, Paulo Henrique; Chen, Xiaochun; Chen, Xiaowei; Clarkson, Andrew N.The global trend toward aging populations has resulted in an increase in the occurrence of Alzheimer's disease (AD) and associated socio-economic burdens. Abnormal metabolism of amyloidâ β (Aβ) has been proposed as a signiï¬ cant pathomechanism in AD, supported by results of recent clinical trials using antiâ Aβ antibodies. Nonetheless, the cognitive beneï¬ ts of the current treatments are limited. The etiol...
Triiodothyronine modulates neuronal plasticity mechanisms to enhance functional...
Talhada, Daniela; Feiteiro, Joana; Costa, Ana Raquel; Talhada, Tiago; Cairrão, Elisa; Wieloch, Tadeusz; Englund, Elisabet; Santos, Cecilia ReisThe development of new therapeutic approaches for stroke patients requires a detailed understanding of the mechanisms that enhance recovery of lost neurological functions. The efficacy to enhance homeostatic mechanisms during the first weeks after stroke will influence functional outcome. Thyroid hormones (TH) are essential regulators of neuronal plasticity, however, their role in recovery related mechanisms of...
MicroRNA-124-loaded nanoparticles increase survival and neuronal differentiatio...
Saraiva, Cláudia; Talhada, Daniela; Rai, Akhilesh; Ferreira, Raquel; Ferreira, Lino; Bernardino, Liliana; Ruscher, KarstenThere is a high quest for novel therapeutic strategies to enhance recovery after stroke. MicroRNA-124 (miR-124) has been described as neuroprotective and anti-inflammatory molecule. Moreover, miR-124 is a well described enhancer of adult neurogenesis that could offer potentially beneficial effects. Herein, we used miR-124-loaded nanoparticles (miR-124 NPs) to evaluate their therapeutic potential in an in vitro ...