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Long-term cardiometabolic health in people born after assisted reproductive tec...

Elhakeem, A; Taylor, AE; Inskip, HM; Huang, JY; Mansell, T; Rodrigues, C; Asta, F; Blaauwendraad, SM; Haberg, SE; Halliday, J; Harskamp-van Ginkel, MW

Aims To examine associations of assisted reproductive technology (ART) conception (vs. natural conception: NC) with offspring cardiometabolic health outcomes and whether these differ with age. Methods and results Differences in systolic (SBP) and diastolic blood pressure (DBP), heart rate (HR), lipids, and hyperglycaemic/insulin resistance markers were examined using multiple linear regression models in 14 popu...


Changes in parental smoking during pregnancy and risks of adverse birth outcome...

Philips, EM; Santos, S; Trasande, L; Aurrekoetxea, JJ; Barros, H; von Berg, A; Bergström, A; Bird, PK; Brescianini, S; Ní Chaoimh, C; Charles, MA

Background. Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, spec...


Mode of Delivery and Asthma at School Age in 9 European Birth Cohorts

Rusconi, F; Zugna, D; Annesi-Maesano, I; Baïz, N; Barros, H; Correia, S; Duijts, L; Forastiere, F; Inskip, H; Kelleher, CC; Larsen, PS; Mommers, M

Evidence on the association between mode of delivery and asthma at school age is inconclusive. We assessed the associations between specific modes of delivery and asthma in children from 9 European birth cohorts that enrolled participants between 1996 and 2006. Cohort-specific crude and adjusted risk ratios for asthma at ages 5–9 years were calculated using Poisson regression models and pooled. A sensitivity an...


Maternal complications in pregnancy and wheezing in early childhood: A pooled a...

Zugna, D; Galassi, C; Annesi-Maesano, I; Baïz, N; Barros, H; Basterrechea, M; Correia, S; Duijts, L; Esplugues, A; Fantini, MP; Forastiere, F; Gascon, M

Background: Evidence on the effect of maternal complications in pregnancy on wheezing in offspring is still insufficient. Methods: A pooled analysis was performed on individual participant data from fourteen European birth cohorts to assess the relationship between several maternal pregnancy complications and wheezing symptoms in the offspring. Exposures of interest included hypertension and preeclampsia, diabe...


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