4 documents found, page 1 of 1
Quantitative genome re-sequencing defines multiple mutations conferring chloroq...
Kinga Modrzynska, Katarzyna; Creasey, Alison; Loewe, Laurence; Cezard, Timothee; Trindade Borges, Sofia; Martinelli, Axel; Rodrigues, LouiseBackground: Drug resistance in the malaria parasite Plasmodium falciparum severely compromises the treatment and control of malaria. A knowledge of the critical mutations conferring resistance to particular drugs is important in understanding modes of drug action and mechanisms of resistances. They are required to design better therapies and limit drug resistance.A mutation in the gene (pfcrt) encoding a membra...
The origins of african Plasmodium vivax; insights from mitochondrial genome seq...
Culleton, Richard; Coban, Cevayir; Zeyrek, Fadile Yildiz; Cravo, Pedro; Kaneko, Akira; Randrianarivelojosia, Milijaona; Andrianaranjaka, VoahangyPlasmodium vivax, the second most prevalent of the human malaria parasites, is estimated to affect 75 million people annually. It is very rare, however, in west and central Africa, due to the high prevalence of the Duffy negative phenotype in the human population. Due to its rarity in Africa, previous studies on the phylogeny of world-wide P. vivax have suffered from insufficient samples of African parasites. H...
Failure to detect Plasmodium vivax in West and Central Africa by PCR species ty...
Culleton, Richard L.; Mita, Toshihiro; Ndounga, Mathieu; Unger, Holger; Cravo, Pedro V.L.; Paganotti, Giacomo M.; Takahashi, Nobuyuki; Kaneko, AkiraBackground. Plasmodium vivax is estimated to affect 75 million people annually. It is reportedly absent, however, from west and central Africa due to the high prevalence of the Duffy negative phenotype in the indigenous populations. Despite this, non-African travellers consistently return to their own countries with P. vivax malaria after visiting this region. An attempt was made, therefore, to detect the prese...
An AFLP-based genetic linkage map of Plasmodium chabaudi chabaudi
Martinelli, Axel; Hunt, Paul; Fawcett, Richard; Cravo, Pedro V L; Walliker, David; Carter, RichardBACKGROUND: Plasmodium chabaudi chabaudi can be considered as a rodent model of human malaria parasites in the genetic analysis of important characters such as drug resistance and immunity. Despite the availability of some genome sequence data, an extensive genetic linkage map is needed for mapping the genes involved in certain traits. METHODS: The inheritance of 672 Amplified Fragment Length Polymorphism (AFLP...