4 documents found, page 1 of 1
The actin-binding protein α-adducin is required for maintaining axon diameter
Leite, SC; Sampaio, P; Sousa, VF; Nogueira-Rodrigues, J; Pinto-Costa, R; Peters, LL; Brites, P; Sousa, MMThe actin-binding protein adducin was recently identified as a component of the neuronal subcortical cytoskeleton. Here, we analyzed mice lacking adducin to uncover the function of this protein in actin rings. a-adducin knockout mice presented progressive axon enlargement in the spinal cord and optic and sciatic nerves, followed by axon degeneration and loss. Using stimulated emission depletion super-resolution...
Poly(trimethylene carbonate-co-e-caprolactone) promotes axonal growth
Rocha, DN; Brites, P; Fonseca, C; Pêgo, APMammalian central nervous system (CNS) neurons do not regenerate after injury due to the inhibitory environment formed by the glial scar, largely constituted by myelin debris. The use of biomaterials to bridge the lesion area and the creation of an environment favoring axonal regeneration is an appealing approach, currently under investigation. This work aimed at assessing the suitability of three candidate pol...
Peripheral nervous system plasmalogens regulate Schwann cell differentiation an...
Silva, TF; Eira, J; Lopes, AT; Malheiro, AR; Sousa, V; Luoma, A; Avila, RL; Wanders, RJ; Just, WW; Kirschner, DA; Sousa, MM; Brites, PRhizomelic chondrodysplasia punctata (RCDP) is a developmental disorder characterized by hypotonia, cataracts, abnormal ossification, impaired motor development, and intellectual disability. The underlying etiology of RCDP is a deficiency in the biosynthesis of ether phospholipids, of which plasmalogens are the most abundant form in nervous tissue and myelin; however, the role of plasmalogens in the peripheral ...
A PEX7-centered perspective on the peroxisomal targeting signal type 2-mediated...
Rodrigues, TA; Alencastre, IS; Francisco, T; Brites, P; Fransen, M; Grou, CP; Azevedo, JEPeroxisomal matrix proteins are synthesized on cytosolic ribosomes and transported to the organelle by shuttling receptors. Matrix proteins containing a type 1 signal are carried to the peroxisome by PEX5, whereas those harboring a type 2 signal are transported by a PEX5-PEX7 complex. The pathway followed by PEX5 during the protein transport cycle has been characterized in detail. In contrast, not much is known...