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Extreme Temperatures and Stroke Mortality: Evidence From a Multi-Country Analysis

Alahmad, Barrak; Khraishah, Haitham; Kamineni, Meghana; Royé, Dominic; Papatheodorou, Stefania I.; Vicedo-Cabrera, Ana Maria; Guo, Yuming; Lavigne, Eric

Background: Extreme temperatures contribute significantly to global mortality. While previous studies on temperature and stroke-specific outcomes presented conflicting results, these studies were predominantly limited to single-city or single-country analyses. Their findings are difficult to synthesize due to variations in methodologies and exposure definitions. Methods: Within the Multi-Country Multi-City Netw...


All-cause, cardiovascular, and respiratory mortality and wildfire-related ozone...

Chen, Gongbo; Guo, Yuming; Yue, Xu; Xu, Rongbin; Yu,Wenhua; Ye, Tingting; Tong, Shilu; Gasparrini, Antonio; Bell,Michelle L.; Armstrong, Ben

Background: Wildfire activity is an important source of tropospheric ozone (O3) pollution. However, no study to date has systematically examined the associations of wildfire-related O3 exposure with mortality globally. Methods: We did a multicountry two-stage time series analysis. From the Multi-City Multi-Country (MCC) Collaborative Research Network, data on daily all-cause, cardiovascular, and respiratory dea...


Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mor...

Alahmad, Barrak; Khraishah, Haitham; Royé, Dominic; Vicedo-Cabrera, Ana Maria; Guo, Yuming; Papatheodorou, Stefania I.; Achilleos, Souzana

Background: Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths. Methods: We used unified data collection protocols within the Multi-Country Multi-City Collab...


Differential Mortality Risks Associated With PM2.5 Components: A Multi-Country,...

Masselot, Pierre; Sera, Francesco; Schneider, Rochelle; Kan, Haidong; Lavigne, Éric; Stafoggia, Massimo; Tobias, Aurelio; Chen, Hong

Background: The association between fine particulate matter (PM2.5) and mortality widely differs between as well as within countries. Differences in PM2.5 composition can play a role in modifying the effect estimates, but there is little evidence about which components have higher impacts on mortality. Methods: We applied a 2-stage analysis on data collected from 210 locations in 16 countries. In the first stag...


Geographical Variations of the Minimum Mortality Temperature at a Global Scale

Tobías, Aurelio; Hashizume, Masahiro; Honda, Yasushi; Sera, Francesco; Ng, Chris Fook Sheng; Kim, Yoonhee; Roye, Dominic; Chung, Yeonseung

Background: Minimum mortality temperature (MMT) is an important indicator to assess the temperature-mortality association, indicating long-term adaptation to local climate. Limited evidence about the geographical variability of the MMT is available at a global scale. Methods: We collected data from 658 communities in 43 countries under different climates. We estimated temperature-mortality associations to deriv...


Ambient carbon monoxide and daily mortality: a global time-series study in 337 ...

Chen, Kai; Breitner, Susanne; Wolf, Kathrin; Stafoggia, Massimo; Sera, Francesco; Vicedo-Cabrera, Ana M.; Guo, Yuming; Tong, Shilu; Lavigne, Eric

Background: Epidemiological evidence on short-term association between ambient carbon monoxide (CO) and mortality is inconclusive and limited to single cities, regions, or countries. Generalisation of results from previous studies is hindered by potential publication bias and different modelling approaches. We therefore assessed the association between short-term exposure to ambient CO and daily mortality in a ...


Mortality risk attributable to wildfire-related PM2·5 pollution: a global time ...

Chen, Gongbo; Guo, Yuming; Yue, Xu; Tong, Shilu; Gasparrini, Antonio; Bell, Michelle L.; Armstrong, Ben; Schwartz, Joel; Jaakkola, Jouni J.K.

Background: Many regions of the world are now facing more frequent and unprecedentedly large wildfires. However, the association between wildfire-related PM2·5 and mortality has not been well characterised. We aimed to comprehensively assess the association between short-term exposure to wildfire-related PM2·5 and mortality across various regions of the world. Methods: For this time series study, data on daily ...


Projections of excess mortality related to diurnal temperature range under clim...

Lee, Whanhee; Kim, Yoonhee; Sera, Francesco; Gasparrini, Antonio; Park, Rokjin; Michelle Choi, Hayon; Prifti, Kristi; Bell, Michelle L.

Background: Various retrospective studies have reported on the increase of mortality risk due to higher diurnal temperature range (DTR). This study projects the effect of DTR on future mortality across 445 communities in 20 countries and regions. Methods: DTR-related mortality risk was estimated on the basis of the historical daily time-series of mortality and weather factors from Jan 1, 1985, to Dec 31, 2015, ...


Ambient particulate air pollution and daily mortality in 652 cities

Liu, Cong; Chen, Renjie; Sera, Francesco; Vicedo-Cabrera, Ana M.; Guo, Yuming; Tong, Shilu; Coelho, Micheline S.Z.S.; Saldiva, Paulo H.N.; Lavigne, Eric

The systematic evaluation of the results of time-series studies of air pollution is challenged by differences in model specification and publication bias. We evaluated the associations of inhalable particulate matter (PM) with an aerodynamic diameter of 10 μm or less (PM10) and fine PM with an aerodynamic diameter of 2.5 μm or less (PM2.5) with daily all-cause, cardiovascular, and respiratory mortality across m...


Predicted temperature-increase-induced global health burden and its regional va...

Lee, Jae Young; Kim, Ho; Gasparrini, Antonio; Armstrong, Ben; Bell, Michelle L.; Sera, Francesco; Lavigne, Eric; Abrutzky, Rosana; Tong, Shilu

An increase in the global health burden of temperature was projected for 459 locations in 28 countries worldwide under four representative concentration pathway scenarios until 2099. We determined that the amount of temperature increase for each 100 ppm increase in global CO2 concentrations is nearly constant, regardless of climate scenarios. The overall average temperature increase during 2010-2099 is largest ...


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