3 documents found, page 1 of 1
Physical Interactions With Bacteria and Protozoan Parasites Establish the Scave...
Cardoso, MS; Santos, RF; Almeida, S; Sá, M; Perez-Cabezas, B; Oliveira, L; Tavares, J; Carmo, AMSince the pioneering discoveries, by the Nobel laureates Jules Hoffmann and Bruce Beutler, that Toll and Toll-like receptors can sense pathogenic microorganisms and initiate, in vertebrates and invertebrates, innate immune responses against microbial infections, many other families of pattern recognition receptors (PRRs) have been described. One of such receptor clusters is composed by, if not all, at least sev...
Emerging biosensing technologies for neuroinflammatory and neurodegenerative di...
Abreu, C; Soares-Dos-Reis, R; Melo, PN; Relvas, JB; Guimarães, J; Sá, M; Cruz, AP; Pinto, INeuroinflammation plays a critical role in the onset and progression of many neurological disorders, including Multiple Sclerosis, Alzheimer’s and Parkinson’s diseases. In these clinical conditions the underlying neuroinflammatory processes are significantly heterogeneous. Nevertheless, a common link is the chronic activation of innate immune responses and imbalanced secretion of pro and anti-inflammatory media...
TRSP is dispensable for the Plasmodium pre-erythrocytic phase
Costa, DM; Sá, M; Teixeira, AR; Loureiro, I; Thouvenot, C; Golba, S; Amino, R; Tavares, JPlasmodium sporozoites deposited in the skin following a mosquito bite must migrate and invade blood vessels to complete their development in the liver. Once in the bloodstream, sporozoites arrest in the liver sinusoids, but the molecular determinants that mediate this specific homing are not yet genetically defined. Here we investigate the involvement of the thrombospondin-related sporozoite protein (TRSP) in ...