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Portuguese Consensus for the Evaluation of the Multiple Sclerosis Treatment Res...
Batista, Sónia; Capela, Carlos; Correia, Filipe; Ferreira, João; Guimarães, Joana; Santos, Ernestina; Sá, Maria JoséIntroduction: Multiple sclerosis management has progressed significantly due to the development of novel treatments. Thus, assessing the patients’ treatment response is essential to optimize therapeutic decisions. This study aimed to establish a national consensus on the assessment and monitoring of the response to multiple sclerosis treatment with disease-modifying therapies. Methods: The Delphi methodology wa...
Magnetic Resonance Imaging in Multiple Sclerosis: An Analysis of the Implementa...
Cordeiro, Alyne; Marques, Ana João; Castro, Ana Rita; Silva, Cristiana; Carapinha, Duarte; Ferreira, Francisca; Schön, Miguel; Jardim Pereira, DanielaIntroduction: Magnetic resonance imaging (MRI) plays a critical role in diagnosing and monitoring people with multiple sclerosis (MS). The 2020 Portuguese Consensus on Magnetic Resonance Imaging in Multiple Sclerosis aimed to standardize MRI use. This study evaluated the implementation of the consensus in clinical practice.Methods: This is an observational, retrospective, longitudinal and multicentric study com...
Multiple Sclerosis Relapse Incomplete Recovery and Associated Factors - a Syste...
Ladeira, Filipa; Soares, Mafalda; Faustino, Patrícia; Leal Rato, Miguel; Gomes, Inês; Caetano, André; Taipa, Ricardo; Sá, Maria JoséObjectives: We conducted a meta-analysis to assess the frequency of incomplete recovery from multiple sclerosis (MS) relapses and a systematic review to evaluate the influence of six factors on incomplete recovery: relapse severity, age, sex, disease duration, disease-modifying treatment use, and the presence of contrast-enhancing lesions at relapse. Methods: We searched Scientific databases to identify suitabl...
Multiple Sclerosis Disease-Modifying Treatment Algorithms: 2025 Positioning of ...
Capela, Carlos; Santos, Ernestina; Palavra, Filipe; Guimarães, Joana; Cerqueira, João; Vale, José; Sousa, Lívia; Batista, Sónia; Sá, Maria JoséMultiple sclerosis (MS) is a chronic autoimmune-mediated neurodegenerative disease characterized by inflammation, demyelination, and axonal/neuronal damage in the central nervous system. In Portugal, the prevalence of MS is approximately 64.4 per 100 000 individuals. It is typically diagnosed in young adults aged 30 to 40, with a higher incidence in women, although it can also affect children/adolescents and th...
Prognostic Factors Associated with Disability in a Cohort of Neuromyelitis Opti...
Moura, João; Samões, Raquel; Sousa, Ana Paula; Figueiroa, Sónia; Mendonça, Teresa; Abreu, Pedro; Guimarães, Joana; Melo, Claúdia; Sousa, RaquelIntroduction: Neuromyelitis optica spectrum disorders (NMOSD) and MOG-associated disease (MOGAD) are an increasingly recognized group of demyelinating disorders of the central nervous system. Previous studies suggest that prognosis is predicted by older age at onset, number of relapses, the severity of the first attack and autoantibody status. Objective: To study prognostic factors associated with disability pr...
Consensus for the Early Identification of Secondary Progressive Multiple Sclero...
Sá, Maria José; Basílio, Carlos; Capela, Carlos; Cerqueira, José João; Mendes, Irene; Morganho, Armando; Correia de Sá, João; Salgado, VascoIntroduction: Multiple sclerosis is a disease with a heterogeneous evolution. The early identification of secondary progressive multiple sclerosis is a clinical challenge, which would benefit from the definition of biomarkers and diagnostic tools applicable in the transition phase from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis. We aimed to reach a Portuguese national con...
The Effect of a Healthy Lifestyle on Preventing and Improving Symptoms in Patie...
Silva, Carlos; Ferreira, Francisca; Santos Coelho, Francisco; Sá, Maria José; Guimarães, JoanaIntroduction: Multiple sclerosis (MS) patients expect healthcare professionals to provide them with information on healthy lifestyles. Thus, the purpose of this systematic review is to evaluate and compile measures with scientific evidence related to these lifestyles and to address solutions to the main barriers to their implementation. Methods: Research of articles in the international databases PubMed® and Sc...
Natural history of relapsing remitting multiple sclerosis in a long-lasting coh...
Sá, Maria José; Sequeira, Lucinda; Ferro, Daniela; Marcolino, Adilson; Rocha, Ana Luísa; Seabra, Mafalda; Mendonça, Teresa; Abreu, PedroBackground: Several disease-modifying therapies (DMTs) have emerged in the last two decades for the treatment of multiple sclerosis (MS). The increasing use of these therapies has enhanced the need to study its impact on long-term disease progression and on the natural history of MS. This study aimed to characterize a Portuguese MS patient cohort in what concerns the natural history of disease by exploring diff...
The epidemiology of multiple sclerosis in the entre Douro e Vouga region of nor...
Branco, Mariana; Alves, Ivânia; Martins da Silva, Ana; Pinheiro, Joaquim; Sá, Maria José; Correia, Inês; Sousa, Lívia; Brandão, Eva; Veira, CarlosBackground: The prevalence of Multiple Sclerosis (MS) has been increasing worldwide and the north-south gradient of prevalence may be disappearing in the Northern hemisphere. The few previous prevalence studies performed in Portugal have reported a lower prevalence than the average for Western Europe. The aim of this study is to estimate the prevalence of MS in the Entre Douro e Vouga region, in Northern Portug...
[Recommendations about Multiple Sclerosis Management during Pregnancy, Partum a...
Batista, Sónia; Martins da Silva, Ana; Sá, Maria José; Sousa, Lívia; De Sá, João; Pedrosa, Rui; Cerqueira, João; Pinheiro, Joaquim; Abreu, PedroMultiple sclerosis typically affects young women of reproductive age. Therefore, all healthcare professionals involved in the follow-up of multiple sclerosis patients must be prepared to discuss pregnancy and breastfeeding issues and provide the best possible counselling. However, there are still many doubts and heterogeneous clinical approaches partly due to the lack of consensus and guidelines. Concerning the...