9 documents found, page 1 of 1
Social support network and quality of life in multiple sclerosis patients
Costa,David Castro; Sá,Maria José; Calheiros,José ManuelABSTRACT Objective To analyse the relationship between the social support network (SSN) and health related quality of life (HRQOL) in multiple sclerosis (MS) patients. Methods The sample comprised 150 consecutive MS patients attending our MS clinic. To assess the socio-demographic data, a specifically designed questionnaire was applied. The HRQOL dimensions were measured with the Short-Form Health Survey Questi...
BRBN-T validation: adaptation of the Selective Reminding Test and Word List Gen...
Neves,Mariana Rigueiro; Passos,Ana Margarida; Ferreira,Aristides; Sousa,Cláudia; Sá,Andreia; Sá,Maria JoséObjective This study aims to present the Selective Reminding Test(SRT) and Word List Generation (WLG) adaptation to the Portuguese population, within the validation of the Brief Repeatable Battery of Neuropsychological Tests (BRBN-T)for multiple sclerosis (MS) patients.Method 66 healthy participants (54.5% female) recruited from the community volunteered to participate in this study.Results A combination of pro...
The effect of social support on the quality of life of patients with multiple s...
Costa,David Castro; Sá,Maria José; Calheiros,José M.OBJECTIVE: To determine the predictive value of social support on health related quality of life (HRQoL) in multiple sclerosis (MS) patients. METHODS: The sample is composed by 150 MS consecutive patients. We used the Medical Outcomes Study Social Support Survey to assess social support and the Health Status Questionnaire to assess HRQoL. For inferential analysis, we used the Multiple Linear Regression with ste...
Classical immunomodulatory therapy in multiple sclerosis: how it acts, how it w...
Mendes,Amélia; Sá,Maria JoséInterferon beta (IFNβ) and glatiramer acetate (GA) were the first immunomodulators approved to the treatment of relapsing-remitting multiple sclerosis (MS) and clinically isolated syndromes. Despite the enlargement of the therapeutic armamentarium, IFNβ and GA remain the most widely drugs and the therapeutic mainstay of MS. OBJECTIVE: To review the mechanisms of action of IFNβ and GA and main clinical results i...
Determinação de Anticorpos Anti-Mielina na Esclerose Múltipla
Lima,Eduardo; Guimarães,Joana; Pereira,Ana; Bodas,Abília; Delgado,Luís; Sá,Maria JoséIntrodução: A Esclerose Múltipla é uma doença desmielinizante primária de carácter autoimune, envolvendo diferentes mecanismos imunopatológicos. Pensa-se que anticorpos dirigidos contra antigénios da mielina podem estar associados aos danos na mielina ou surgirem devido a estes, pelo que, o seu doseamento poderá constituir um marcador de evolução da doença. No entanto, a positividade desta pesquisa pode levanta...
Dendritic right/left asymmetries in the neurons of the human hippocampal format...
Sá,Maria José; Ruela,Carlos; Madeira,Maria DulceOBJECTIVE: To search for right/left asymmetries in the dendritic trees of the neuronal populations and in the cell-free layer volumes of the human hipoccampal formation. METHOD: In necropsic material obtained from six male individuals we performed a quantitative Golgi study of the dendritic trees of dentate granules, CA3 and CA1 pyramidal neurons and a volumetric analysis of dentate gyrus molecular layer, strat...
Oligoclonal IgG bands in the cerebrospinal fluid of portuguese patients with mu...
Sá,Maria José; Sequeira,Lucinda; Rio,Maria Edite; Thompson,Edward J.We assessed the frequency of cerebrospinal fluid (CSF) restricted oligoclonal IgG bands (IgG-OCB) in Portuguese multiple sclerosis (MS) patients and its relationship with outcome. Paired CSF/serum samples of 406 patients with neurological disorders were submitted to isoelectric focusing with immunodetection of IgG. Ninety-two patients had definite MS; non-MS cases were assembled in groups inflammatory/infectiou...
Neurossífilis: revisão clínica e laboratorial
Barros,Ana Margarida; Cunha,Ana Paula; Lisboa,Carmen; Sá,Maria José; Resende,As manifestações neurológicas de sífilis tornaram-se raras após a introdução da penicilinoterapia. No entanto, a partir da década de 70, verificou-se um aumentou do número de casos, particularmente em associação com a infecção pelo vírus da imunodeficiência humana. Este aumento da incidência de sífilis, observável também na Europa e nos Estados Unidos da América, poderá traduzir-se num acréscimo do número de ca...
Cerebrospinal fluid cytomorphologic findings in 41 intracranial tumors: a retro...
Sá,Maria José; Vaz,Rui; Cruz,CelsoThe main objective of this retrospective review of clinical and cerebrospinal fluid (CSF) data from 41 patients with intracranial tumors diagnosed between 1975 and 1989, is to report the role that the finding of neoplastic cells in CSF plays, specially when cerebral CT-scanning and MRI were not currently done. Another objective is to study the CSF proteic abnormalities in cerebral tumors. CSF cell count, cytomo...