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Involvement of the chemokine RANTES (CCL5) in resistance to experimental infect...
Santiago, Helton da Costa; Oliveira, Carolina Ferreira; Santiago, Luciana; Ferraz, Fernanda Oliveira; Souza, Daniele da Glória deThe expression and putative role of chemokines during infection with Leishmania major in mice were investigated. CCL5 expression correlates with resistance, and blockade of CCL5 rendered mice more susceptible to infection. CCL5 is part of the cascade of events leading to efficient parasite control in L. major infection.
Early infection with Leishmania major restrains pathogenic response to Leishman...
Lombana, Claudia Zuleida Gonzalez; Santiago, Helton da Costa; Macedo, J. P.; Rego, Virgínia Aparecida Seixas; Russo, Remo de Castro; Tafuri, Wagner LuizExperimental models of infection with Leishmania spp. have provided knowledge of several immunological events involved in the resistance mechanism used by the host to restrain parasite growth. It is well accepted that concomitant immunity exists, and there is some evidence that it would play a major role in long-lasting acquired resistance to infection. In this paper, the resistance to Leishmania amazonensis in...