2 documents found, page 1 of 1
Unravelling a novel role for cannabidivarin in the modulation of subventricular...
Lourenço, Diogo M.; Soares, Rita; Sá Santos, Sónia; Mateus, Joana; Rodrigues, Rui S.; Moreira, João B.; Vaz, Sandra H.; Sebastião, Ana M; Solá, SusanaPostnatal neurogenesis has been shown to rely on the endocannabinoid system. Here we aimed at unravelling the role of Cannabidivarin (CBDV), a non-psychoactive cannabinoid, with high affinity for the non-classical cannabinoid receptor TRPV1, on subventricular zone (SVZ) postnatal neurogenesis. Using the neurosphere assay, SVZ-derived neural stem/progenitor cells (NSPCs) were incubated with CBDV and/or 5'-Iodore...
Neuropeptide kyotorphin (tyrosyl-arginine) has decreased levels in the cerebro-...
Santos, Sara Matos; Garcia-Nimo, Laura; Sá Santos, Sónia; Tavares, Isaura; Cocho, José A.; Castanho, Miguel A. R. B.In Alzheimer’s disease (AD), besides the characteristic deterioration of memory, studies also point to a higher pain tolerance in spite of sensibility preservation. A change in the normal tau protein phosphorylation is also characteristic of AD, which contributes to the pathogenesis of the disease and is useful in early diagnosis. Kyotorphin (KTP) is an endoge-nous analgesic dipeptide (Tyr-Arg) for which there ...