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Clinical standards for antimicrobial stewardship in TB care
Brehm, T T; Akkerman, O W; Sotgiu, G; Tiberi, S; Chang, K-C; Dheda, K; Duarte, Raquel; Vambe, D; Udwadia, Z F; Chesov, D; Mendelson, MBackground: While antimicrobial stewardship (AMS) is essential for combating antimicrobial resistance (AMR), TB-specific AMS strategies remain poorly defined. Methods: An international panel of 62 experts participated in a Delphi process. Using a 5-point Likert scale (5 = strong agreement; 1 = strong disagreement), participants evaluated 10 draft clinical standards developed by a core coordination team. A stand...
Long-term outcomes of the global tuberculosis and COVID-19 co-infection cohort
Casco, N; Jorge, AL; Palmero, DJ; Alffenaar, JW; Fox, GJ; Ezz, W; Cho, JG; Denholm, J; Skrahina, A; Solodovnikova, V; Arbex, MA; Alves, T; Rabahi, MFBackground Longitudinal cohort data of patients with tuberculosis (TB) and coronavirus disease 2019 (COVID-19) are lacking. In our global study, we describe long-term outcomes of patients affected by TB and COVID-19. Methods We collected data from 174 centres in 31 countries on all patients affected by COVID-19 and TB between 1 March 2020 and 30 September 2022. Patients were followed-up until cure, death or end...
Management of patients with multidrug-resistant tuberculosis
Lange, C; Aarnoutse, RE; Alffenaar, JWC; Bothamley, G; Brinkmann, F; Costa, J; Chesov, D; van Crevel, R; Dedicoat, M; Dominguez, J; Duarte, RThe emergence of multidrug-resistant tuberculosis (MDR-TB; defined as resistance to at least rifampicin and isoniazid) represents a growing threat to public health and economic growth. Never before in the history of mankind have more patients been affected by MDR-TB than is the case today. The World Health Organization reports that MDR-TB outcomes are poor despite staggeringly high management costs. Moreover, t...
The Tuberculosis Network European Trials group (TBnet) ERS Clinical Research Co...
van Leth, F; Brinkmann, F; Cirillo, DM; Dheda, K; Duarte, R; Guglielmetti, L; Kuksa, L; Lange, C; Mitnick, C; Skrahina, A; Zaman, K; Bothamley, Gn/a
Recombination in pe/ppe genes contributes to genetic variation in Mycobacterium...
Phelan, JE; Coll, F; Bergval, I; Anthony, RM; Warren, R; Sampson, SL; Gey van Pittius, NC; Glynn, JR; Crampin, AC; Alves, A; Bessa, TB; Campino, SBackground: Approximately 10% of the Mycobacterium tuberculosis genome is made up of two families of genes that are poorly characterized due to their high GC content and highly repetitive nature. The PE and PPE families are typified by their highly conserved N-terminal domains that incorporate proline-glutamate (PE) and proline-proline-glutamate (PPE) signature motifs. They are hypothesised to be important viru...