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Changes in parental smoking during pregnancy and risks of adverse birth outcome...

Philips, EM; Santos, S; Trasande, L; Aurrekoetxea, JJ; Barros, H; von Berg, A; Bergström, A; Bird, PK; Brescianini, S; Ní Chaoimh, C; Charles, MA

Background. Fetal smoke exposure is a common and key avoidable risk factor for birth complications and seems to influence later risk of overweight. It is unclear whether this increased risk is also present if mothers smoke during the first trimester only or reduce the number of cigarettes during pregnancy, or when only fathers smoke. We aimed to assess the associations of parental smoking during pregnancy, spec...


Maternal body mass index, gestational weight gain, and the risk of overweight a...

Voerman, E; Santos, S; Patro Golab, B; Amiano, P; Ballester, F; Barros, H; Bergström, A; Charles, MA; Chatzi, L; Chevrier, C; Chrousos, GP

Maternal obesity and excessive gestational weight gain may have persistent effects on offspring fat development. However, it remains unclear whether these effects differ by severity of obesity, and whether these effects are restricted to the extremes of maternal body mass index (BMI) and gestational weight gain. We aimed to assess the separate and combined associations of maternal BMI and gestational weight gai...


Is it acceptable to use animals to model obese humans? - A critical discussion ...

Lund, TB; Sørensen, TIA; Olsson, IAS; Hansen, AK; Sandøe, P

Animal use in medical research is widely accepted on the basis that it may help to save human lives and improve their quality. Recently, however, objections have been made specifically to the use of animals in scientific investigation of human obesity. This paper discusses two arguments for the view that this form of animal use, unlike some other forms of animal-based medical research, cannot be defended. The f...


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