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Whole-genome sequencing as a tool for studying the microevolution of drug-resis...

Diniz, Jaciara; von Groll, Andrea; Unis, Gisela; Dalla-Costa, Elis Regina; Rosa Rossetti, Maria Lúcia; Vianna, Júlia Silveira; Ramos, Daniela Fernandes

Treatment of drug-resistant tuberculosis requires extended use of more toxic and less effective drugs and may result in retreatment cases due to failure, abandonment or disease recurrence. It is therefore important to understand the evolutionary process of drug resistance in Mycobacterium tuberculosis. We here in describe the microevolution of drug resistance in serial isolates from six previously treated patie...

Date: 2021   |   Origin: Repositório da Universidade de Lisboa
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