7 documents found, page 1 of 1
Drosophila motor neuron boutons remodel through membrane blebbing coupled with ...
Fernandes, Andreia R.; Martins, João P.; Gomes, Edgar R.; S. Mendes, César; Teodoro, RitaFunding Information: We would like to thank Telmo Pereira from the Microscopy Facility for technical support, the Fly Facility at Nova Medical Research; CONGENTO: consortium for genetically tractable organisms. We thank the Developmental Studies Hybridoma Bank, Bloomington Drosophila Stock Center and VDRC for antibodies and fly stocks. This work was supported by PTDC-01778/2022- NeuroDev3D to R.O.T. GEMiNI and ...
Genipin prevents alpha-synuclein aggregation and toxicity by affecting endocyto...
Rosado-Ramos, Rita; Poças, Gonçalo M.; Marques, Daniela; Foito, Alexandre; M Sevillano, David; Lopes-da-Silva, Mafalda; Gonçalves, Luís G.Parkinson's Disease (PD) is a common neurodegenerative disorder affecting millions of people worldwide for which there are only symptomatic therapies. Small molecules able to target key pathological processes in PD have emerged as interesting options for modifying disease progression. We have previously shown that a (poly)phenol-enriched fraction (PEF) of Corema album L. leaf extract modulates central events in...
Motor dysfunction in Drosophila melanogaster as a biomarker for developmental n...
Cabrita, Ana; Medeiros, Alexandra M; Pereira, Telmo; Rodrigues, António Sebastião; Kranendonk, Michel; S. Mendes, César752891, GEMiNI to CSM), Fundac¸ a˜ o para a Cieˆ ncia e a Tecnologia (FCT) (PTDC/ BIA-COM/0151/2020, iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), and LS4FUTURE (LA/P/ 0087/2020) to CSM). AM was supported by a doctoral fellowship from FCT (PD/BD/128445/2017). ASR and MK were partially supported by grant UID/BIM/0009/2020 for the Research Center for Toxicogenomics and Human Health - (ToxOmics) from FCT, Po...
Erratum
Skarlatou, Sophie; Hérent, Coralie; Toscano, Elisa; S. Mendes, César; Bouvier, Julien; Zampieri, Niccolò(Cell Reports 31, 107741-1–107741-14.e1–e4; June 9, 2020) In the originally published version of this article, three experiments were not described in the STAR Methods section. These were the preparation of isolated spinal cords, the analysis of fictive locomotion data, and three-dimensional positional analysis. These experiments have now been described in the article online. In addition, Talpalar et al. (2011)...
The steroid-hormone ecdysone coordinates parallel pupariation neuromotor and mo...
Heredia, Fabiana; Volonté, Yanel; Pereirinha, Joana; Fernandez-Acosta, Magdalena; Casimiro, Andreia P.; Belém, Cláudia G.; Viegas, FilipeFunding Information: We thank Drs. Carlos Ribeiro, Christen Mirth, Elio Sucena, Filip Port, Frank Schnorrer, Julien Colombani, Maria Dominguez, Maria Luisa Vasconcelos, Pierre Leopold, Simon Bullock, Rita Teodoro, Gerald Rubin, Melissa Harrison, Kate O’Connor-Giles, Jill Wildonger, Mariana Melani, Pablo Wappner, and Christian Wegener for fly stocks and reagents. We thank Ryohei Yagi and Konrad Basler for the LH...
Afadin Signaling at the Spinal Neuroepithelium Regulates Central Canal Formatio...
Skarlatou, Sophie; Hérent, Coralie; Toscano, Elisa; S. Mendes, César; Bouvier, Julien; Zampieri, NiccolòSkarlatou et al. report that afadin function in the developing spinal neuroepithelium controls organization of the midline. Afadin elimination from the motor neuron progenitor zone results in duplication of the central canal, aberrant wiring of dI4-5, V0, and V2a premotor neurons, and loss of left-right limb alternation.
Quantification of gait parameters in freely walking rodents
S. Mendes, César; Bartos, Imre; Márka, Zsuzsanna; Akay, Turgay; Márka, Szabolcs; Mann, Richard S.Background: Qualitative and quantitative measurements of motor performance are essential for characterizing perturbations of motor systems. Although several methods exist for analyzing specific motor tasks, few behavioral assays are readily available to researchers that provide a complete set of kinematic parameters in rodents. Results: Here we present MouseWalker, an integrated hardware and software system tha...