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Evidence for an association of prenatal exposure to particulate matter with cli...
Xavier Santos, João; Sampaio, Pedro; Rasga, Célia; Martiniano, Hugo; Farias, Clarissa; Café, Cátia; Oliveira, Alexandra; Duque, F; Oliveira, GuiomarEarly-life exposure to air pollutants, including ozone (O3), particulate matter (PM2.5 or PM10, depending on diameter of particles), nitrogen dioxide (NO2) and sulfur dioxide (SO2) has been suggested to contribute to the etiology of Autism Spectrum Disorder (ASD). In this study, we used air quality monitoring data to examine whether mothers of children with ASD were exposed to high levels of air pollutants duri...
Validation of the international 7-item falls efficacy scale in portuguese commu...
Marques-Vieira, Cristina; Sousa, Luís; Baixinho, Cristina Lavareda; Reis, Maria Gorete Mendonça dos; Pérez-Riva, Francisco Javier; SOUSA, LISETEObjective to determine the psychometric properties of the international 7-item Falls Efficacy Scale. Method a psychometric study. Convenience sample consisting of 170 older adults living in the Madeira Autonomous Region, Portugal. A two-part instrument was used (sociodemographic characterization and the Falls Efficacy Scale-International-Portugal). The starting point was the translation and transcultural adapta...
COVID-19: nothing is normal in this pandemic
Gonçalves, Luzia; Turkman; Brás-Geraldes, Carlos; Marques, Tiago A.; SOUSA, LISETEThis manuscript brings attention to inaccurate epidemiological concepts that emerged during the COVID-19 pandemic. In social media and scientific journals, some wrong references were given to a "normal epidemic curve" and also to a "log-normal curve/distribution". For many years, textbooks and courses of reputable institutions and scientific journals have disseminated misleading concepts. For example, calling h...
Use of chemometrics in the selection of a Saccharomyces cerevisiae expression s...
Sampaio, P. N.; SOUSA, LISETE; Calado, Cecília; Pais, M. S.; Fonseca\, L. P.Two multivariate statistical methods, factor analysis (FA) and hierarchical cluster analysis (HCA), were applied to experimental data set to evaluate their usefulness in selecting the adequate expression system and optimal growth parameters for recombinant cyprosin B production. Using FA, the large data set was reduced to two factors representing 73.4% of variability. Factor 1, with 53.5% of variability, corres...
Optimization of the culture medium composition using response surface methodolo...
Sampaio, Pedro; Calado, Cecília; SOUSA, LISETE; Bressler, David C.; Pais, Maria Salomé; Fonseca, Luís P. P.The optimization of culture medium composition was carried out for improvement the recombinant cyprosin B production, an enzyme with high milk-clotting activity. Response surface methodology (RSM) was applied to evaluate the effect of variables namely glucose, yeast extract (YE) and bactopeptone present in the culture medium, used for recombinant cyprosin B production by transformed Saccharomyces cerevisiae BJ1...