9 documents found, page 1 of 1
A Comparative Analysis of the Venom System between Two Morphotypes of the Sea A...
Alcaide, Maria; Moutinho Cabral, Inês; Carvalho, Lara; Mendes, Vera M.; Alves de Matos, António P.; Manadas, Bruno; Saúde, LeonorFundo Azul co-financed project MARVEN (FA_05_2017_007). The Portuguese Foundation for Science and Technology (FCT), i.p., is acknowledged for funding the projects UIDP/04378/2020 and UIDB/04378/2020 of the Research Unit on Applied Molecular Biosciences-UCIBIO and the project LA/P/0140/2020 of the Associate Laboratory Institute for Health and Bioeconomy-i4HB; UIDB/04539/2020, UIDP/04539/2020 and LA/P/0058/2020, ...
A mechanistic study on the interaction effects between legacy and pollutants of...
Martins, Carla; Carvalho, Lara M.; Cabral, Inês Moutinho; Saúde, Leonor; Dreij, Kristian; Costa, Pedro M.We are also thankful to C. Gon\u00E7alves and M. D'Ambrosio (UCIBIO) for assistance with the Comet assay protocol. Publisher Copyright: © 2024 The Authors; To study the intricate toxicological mechanisms triggered by exposure to mixed pollutants, we exposed zebrafish embryos to legacy and emerging pollutants through binary mixtures of benzo[a]pyrene (B[a]P) and diclofenac (DFC). The combination of next-generati...
Using the MouseWalker to Quantify Locomotor Dysfunction in a Mouse Model of Spi...
Isidro, Ana Filipa; Medeiros, Alexandra M.; Martins, Isaura; Neves-Silva, Dalila; Saúde, Leonor; Mendes, César S.This work was supported by Fundação para a Ciência e a Tecnologia (FCT) (PTDC/BIA-COM/0151/2020), iNOVA4Health (UIDB/04462/2020 and UIDP/04462/2020), and LS4FUTURE (LA/P/0087/2020) to C.S.M. L.S. was supported by a CEEC Individual Principal Investigator contract (2021.02253.CEECIND). A.F.I. was supported by a doctoral fellowship from FCT (2020.08168.BD). A.M.M. was supported by a doctoral fellowship from FCT (P...
The right time for senescence
De-Carvalho, Diogo Paramos; Jacinto, Antonio; Saúde, LeonorFunding: We are truly grateful to Pedro Sousa-Vitor, Miguel Godinho-Ferreira, and Mariana AscençãoFerreira for critical reading of the manuscript. This work was supported by a FCT PhD Fellowship (PD/BD/105770/2014) to DPC, and co-funded by the FCT (PTDC/MED-NEU/30428/2017), 'la Caixa' Banking Foundation and FCT, IP, under project code HR18-00187 and SCML Melo e Castro Award (MC36-2020).; Cellular senescence is ...
Targeting senescent cells improves functional recovery after spinal cord injury
Paramos-de-Carvalho, Diogo; Martins, Isaura; Cristóvão, Ana Margarida; Dias, Ana Filipa; Neves-Silva, Dalila; Pereira, Telmo; Chapela, DianaFunding Information: We are grateful to A. Nascimento, A. Temudo, and J. Rino from the Bioimaging Unit for all of their precious advice. We thank the support given by the Fish and Rodent Facilities and the Histology and Comparative Pathology Laboratory, A. Ribeiro and C. de Sena-Tomás for critical reading of the manuscript, and M. Rebocho-da-Costa for help with the graphical abstract. D.P.d.C. was supported by ...
Identification of Dmrt2a downstream genes during zebrafish early development us...
Pinto, Rita Alexandra; Almeida-Santos, José; Lourenço, Raquel; Saúde, LeonorThis research was supported by FCT (Portugal) grant (PTDC/SAU-BID/119627/2010) given to L.S. L.S. was supported by an IF contract from FCT (Portugal). R.A.P. was supported by a PhD fellowship (SFRH/BD/87607/2012) from FCT (Portugal). Publication was sponsored by LISBOA-01-0145-FEDER-007391, project co-funded by FEDER through POR Lisboa 2020 - Programa Operacional Regional de Lisboa, PORTUGAL 2020 and by Fundaca...
Notch/Her12 signalling modulates, motile/immotile cilia ratio downstream of Fox...
Tavares, Barbara; Jacinto, Raquel; Sampaio, Pedro; Pestana, Sara; Pinto, Andreia; Vaz, Andreia; Roxo-Rosa, Mónica; Gardner, Rui; Lopes, Telmaundacao para a Ciencia e a Tecnologia PTDC/BEX-BID/1411/2014 Susana Santos Lopes Fundacao para a Ciencia e a Tecnologia FCT-ANR/BEX-BID/0153/2012 Sara Pestana Fundacao para a Ciencia e a Tecnologia PTDC/SAU-OBD/103981/2008 Andreia Vaz Fundacao para a Ciencia e a Tecnologia PD/BD/52420/2013 Raquel Jacinto Fundacao para a Ciencia e a Tecnologia SFRH/BPD/77258/2011 Barbara Tavares Fundacao para a Ciencia e a Tecno...
An amputation resets positional information to a proximal identity in the regen...
Azevedo, Ana Sofia; Sousa, Sara; Jacinto, Antonio; Saúde, LeonorWe thank Lara Carvalho and Fabio Valerio for excellent zebrafish husbandry, Andreia Pinto for histology and Antonio Temudo for imaging support. We are grateful to C. Certal and S. Pascoal for comments on the manuscript. A. S. A and S. S were supported by FCT fellowships (SFRH/BD/33179/2007 and SFER/BD/32952/2006). L. S. was supported by two FCT grants (PTDC/SAU-OBD/64628/2006 and PTDC/SAU-OBD/100202/2008) and A...
In Vivo Cell and Tissue Dynamics Underlying Zebrafish Fin Fold Regeneration
Mateus, Rita; Pereira, Telmo; Sousa, Sara; de Lima, Joana Esteves; Pascoal, Susana; Saúde, Leonor; Jacinto, AntonioBackground: Zebrafish (Danio rerio) has a remarkable capacity to regenerate many organs and tissues. During larval stages the fin fold allows the possibility of performing long time-lapse imaging making this system very appealing to study the relationships between tissue movements, cell migration and proliferation necessary for the regeneration process. Results: Through the combined use of transgenic fluorescen...