7 documents found, page 1 of 1
Knockdown of transglutaminase-2 prevents early age-induced vascular changes in ...
Armstrong,Dinani Matoso Filho; Sikka,Gautam; Armstrong,Anderson da Costa; Saad,Karen Ruggeri; Freitas,William Rodrigues de; Berkowitz,Dan EzraAbstract Purpose: To determine whether the absence of transglutaminase 2 enzyme (TG2) in TG2 knockout mice (TG2-/-) protect them against early age-related functional and histological arterial changes. Methods: Pulse wave velocity (PWV) was measured using non-invasive Doppler and mean arterial pressure (MAP) was measured in awake mice using tail-cuff system. Thoracic aortas were excised for evaluation of endothe...
Animal model of continuous peritoneal lavage with vacuum peritoneostomy
Rodrigues,Adilson Costa; Santos,Luana Carla Dos; Otsuki,Denise Aya; Saad,Karen Ruggeri; Saad,Paulo Fernandes; Montero,Edna Frasson de SouzaAbstract Purpose: To establish and evaluate the feasibility of continuous peritoneal lavage with vacuum peritoneostomy in an animal model. Methods: Eight pigs aged 3-4 months, females, were anesthetized and submitted to laparotomy and installation of a continuous peritoneal lavage with vacuum peritoneostomy. The sta-bility of the system, the physiological effects of washing with NaCl 0.9% and the sys-tem cleara...
Dilatation of Common Iliac Arteries after Endovascular Infrarenal Abdominal Aor...
Telles,Gustavo José Politzer; Razuk Filho,Álvaro; Karakhanian,Walter Khegan; Saad,Paulo Fernandes; Saad,Karen Ruggeri; Park,Jong HunAbstract Objective: Endovascular techniques to treat abdominal aortic aneurysms results in lower morbidity and mortality rates. However, dilation of the common iliac arteries prevents adequate distal sealing, which compromises the procedure success. The aim of this study is report the long-term outcomes of patients with abdominal aortic aneurysms associated with aneurysm of the common iliac artery following end...
Remote ischemic preconditioning and tacrolimus in the fetal small bowel transpl...
Morello,Ricardo José; Koike,Marcia Kiyomi; Abrahão,Marcos de Souza; Saad,Karen Ruggeri; Saad,Paulo Fernandes; Montero,Edna Frasson de SouzaABSTRACT PURPOSE: To evaluate the effect of remote ischemic preconditioning (IPC-R) in the fetal small bowel transplantation model. METHODS: Two groups were constituted: The Isogenic transplant (ISO, C57BL/6 mice, n=24) and the allogenic transplant (ALO, BALB/c mice, n=24). In each group, the animals were distributed with and without IPC-R. It was obtained the following subgroups: Tx, IPC-R, Fk, IPC-Fk, in both...
Effect of N-acetylcysteine in hearts of rats submitted to controlled hemorrhagi...
Oliveira Filho,Luiz Dantas de; Saad,Karen Ruggeri; Saad,Paulo Fernandes; Koike,Marcia Kiyomi; Silva,Sônia Maria da; Montero,Edna Frasson de SouzaAbstractIntroduction:Pharmacological therapy is a strategy for the prevention of complications associated with ischemia and reperfusion injury that occurs after volume replacement in the treatment of hemorrhagic shock.Objective:The aim of this study was to evaluate the effect of N-acetylcysteine associated with fluid resuscitation in cardiac injury in a rat hemorrhagic shock model.Methods:Mice Wister male rats ...
Effects of ischemic preconditioning and cilostazol on muscle ischemia-reperfusi...
Frias Neto,Carlos Alberto da Silva; Koike,Márcia Kiyomi; Saad,Karen Ruggeri; Saad,Paulo Fernandes; Montero,Edna Frasson de SouzaPURPOSE: To evaluate effects of ischemic preconditioning and Cilostazol on muscle ischemia-reperfusion injury. METHODS: Male Wistar rats were submitted to muscle ischemic and reperfusion injury (4h of the left common iliac artery occlusion followed by 1h of reperfusion). Five experimental groups were constituted: Control group (n=4); Ischemia-Reperfusion (IR, n=5); Ischemic preconditioning group (IP, n=6); Isch...
Effect of N-acetylcysteine on pulmonary cell death in a controlled hemorrhagic ...
Saad,Paulo Fernandes; Saad,Karen Ruggeri; Oliveira Filho,Luiz Dantas de; Ferreira,Sueli Gomes; Koike,Marcia Kiyomi; Montero,Edna Frasson de SouzaPURPOSE: To evaluate the effect of N-acetylcysteine (NAC) combined with fluid resuscitation on pulmonary cell death in rats induced with controlled hemorrhagic shock (HS). METHODS: Two arteries (MAP calculation and exsanguination) and one vein (treatments) were catheterized in 22 anesthetized rats. Two groups of male albino rats were induced with controlled HS at 35mmHg MAP for 60 min. After this period, the RL...