22 documents found, page 1 of 3
New insights on antibacterial mode of action of blue-light photoactivated berbe...
Gonsalves, ASC; Fernandes, JR; Saavedra, MJ; Guimaraes, NM; Pereira, C; Simoes, M; Anabela Borges; Simões MAntimicrobial photodynamic inactivation (aPDI), using photosensitisers in combination with antibiotics, is a promising multi-target strategy to address antibiotic resistance, particularly in wound infections. This study aimed to elucidate the antibacterial mode of action of combinations of berberine (Ber) or curcumin (Cur) with selected antibiotics (Ber-Ab or Cur-Ab) under blue light irradiation (420 nm) agains...
Photodynamic activation of phytochemical-antibiotic combinations for combatting...
Gonçalves, ASC; Leitao, MM; Fernandes, JR; Saavedra, MJ; Pereira, C; Simoes, M; Anabela Borges; Simões MStaphylococcus aureus is characterized by its high resistance to conventional antibiotics, particularly methicillinresistant (MRSA) strains, making it a predominant pathogen in acute and chronic wound infections. The persistence of acute S. aureus wound infections poses a threat by increasing the incidence of their chronicity. This study investigated the potential of photodynamic activation using phytochemical-...
Hydrocinnamic Acid and Perillyl Alcohol Potentiate the Action of Antibiotics ag...
Sousa, M; Afonso, AC; Teixeira, LS; Anabela Borges; Saavedra, MJ; Simões, LC; Simões, M; Simões MThe treatment of bacterial infections has been troubled by the increased resistance to antibiotics, instigating the search for new antimicrobial therapies. Phytochemicals have demonstrated broad-spectrum and effective antibacterial effects as well as antibiotic resistance-modifying activity. In this study, perillyl alcohol and hydrocinnamic acid were characterized for their antimicrobial action against Escheric...
Screening of Natural Molecules as Adjuvants to Topical Antibiotics to Treat Sta...
Oliveira, D; Anabela Borges; Saavedra, MJ; Fernanda Borges; Simoes, M; Simões MDiabetic foot ulcers (DFUs) are a common result of a complex secondary complication of diabetes mellitus. More than half of DFUs become infected due to frequent colonization with Staphylococcus aureus. The use of topical antibiotics is proposed, especially in combination with natural adjuvants, to minimize the negative impacts caused by generalized use of systemic antibiotics. In this study, 13 different phytoc...
Highly pathogenic Aeromonas hydrophila in swine
Duarte, EL; Queiroga, Maria Cristina; Saavedra, MJOBJECTIVE Autochthonous Iberian pig breeds have been growingly popular due to the increasing demand for locally and extensively produced animals. Due to their different production system, microbiological hazards significantly diverge from industrially reared animals. Within the frame of a broader study to characterize specific pathogens associated with Alentejano pig breed, Aeromonas hydrophila was isolated in ...
Particularidades na patologia do porco Alentejano
Queiroga, Maria Cristina; Saavedra, MJ; Duarte, EA patologia dos suínos que conhecemos e estamos habituados a considerar perante um surto de doença numa exploração suína é baseada em estudos e investigação que assentam em ocorrências em animais criados em regime intensivo. O porco Alentejano é explorado em regime extensivo e, apesar da elevada rusticidade da raça, as condições de exploração podem proporcionar o desenvolvimento de patologias, designadamente in...
Fatores de virulência em Aeromonas hydrophila causadora de septicémia em leitões
Saavedra, MJ; Dias, C; Amaral, ASP; Queiroga, Maria CristinaThis work aims to contribute to determine the resistance profile to different antibiotics (ampicillin, gentamicin, penicillin G, oxytetracycline, lincomycin, neomycin, streptomycin, enrofloxacin, colistin sulfate, trimethoprim, sulfamide, tulathromycin, ceftiofur, amoxicillin/clavulanic acid), to assess genetic determinants associated to aminoglycoside antibiotics resistance, namely the presence of genes encodi...
Cortical strut allografting in reconstructive orthopaedic surgery
Judas, F; Saavedra, MJ; Mendes, AF; Dias, RMany approaches are used in the repair of skeletal defects in reconstructive orthopaedic surgery, and bone grafting is involved in virtually every procedure. Autografting remains the gold standard for replacing bone loss. However, the limited amount of bone that can be harvested and the morbidity associated with that procedure are major constraints to the clinical use of autografts. In contrast, bone allografts...
Cortical strut allografting in reconstructive orthopaedic surgery
Judas, F; Saavedra, MJ; Mendes, AF; Dias, RMany approaches are used in the repair of skeletal defects in reconstructive orthopaedic surgery, and bone grafting is involved in virtually every procedure. Autografting remains the gold standard for replacing bone loss. However, the limited amount of bone that can be harvested and the morbidity associated with that procedure are major constraints to the clinical use of autografts. In contrast, bone allografts...
BioRePortAP, an electronic clinical record coupled with a database: an example ...
Campanilho-Marques, R; Polido-Pereira, J; Rodrigues, A; Ramos, F; Saavedra, MJ; Costa, M; Martins, F; Pereira da Silva, JA; Canhão, H; Fonseca, JEAIMS: To evaluate the efficacy and safety of the treatment of psoriatic arthritis (PsA) patients with tumor necrosis factor (TNF) antagonists in the Rheumatology Department of Hospital de Santa Maria using the BioRePortAP. METHODS: The Portuguese Society of Rheumatology (SPR) developed an electronic medical chart coupled with a database for the follow up of PsA patients, the BioRePortAP, which was launched in M...