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Preliminary virtual screening studies to identify grp78 inhibitors which may in...
Palmeira, A; Sousa, E; Köseler, A; Sabirli, R; Gören, T; Türkçüer, I; Kurt, Ö; Pinto, MM; Vasconcelos, MHSARS-CoV-2 Spike protein was predicted by molecular docking to bind the host cell surface GRP78, which was suggested as a putative good molecular target to inhibit Covid-19. We aimed to confirm that GRP78 gene expression was increased in blood of SARS-CoV-2 (+) versus SARS-CoV-2 (-) pneumonia patients. In addition, we aimed to identify drugs that could be repurposed to inhibit GRP78, thus with potential anti-SA...
Date: 2020
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Origin: Repositório Aberto da Universidade do Porto