7 documents found, page 1 of 1
Assessment of the Genotoxic Hazard of Estuarine Sediments Using an Integrative ...
Pinto, Miguel; Sacadura, Joana; Costa, Pedro M.; Caeiro, Sandra; Louro, Henriqueta; Silva, Maria J.Under the influence of multiple anthropogenic pressures, from industrial to agricultural activities, estuaries have long been regarded as particularly sensitive ecosystems to contamination. The present study aimed at investigating the genotoxic potential of a contaminated sediment sample from an urban and industrial area of the Sado Estuary, by combining the analysis of multiple endpoints in the <jats:italic>La...
Toxicity of environmental pollutants: from the bench research to human biomonit...
Pinto, Miguel; Sacadura, Joana; Louro, Henriqueta; Costa, Pedro Manuel; Lavinha, João; Costa, Maria Helena; Caeiro, Sandra; Silva, Maria JoãoBeing subjected to diverse anthropogenic pressures, from industrial to agricultural activities, estuaries have long been regarded as ecosystems particularly sensitive to contamination. A recent study addressed the potential adverse effects of the Portuguese Sado river sediment contaminants on human and ecosystem health. Several complementary approaches were used to assess the effects on human health, including:...
Integrated investigation of the genotoxicity of a contaminated estuary sediment...
Pinto, Miguel; Louro, Henriqueta; Sacadura, Joana; Costa, Pedro M.; Caeiro, Sandra; Silva, Maria JoãoAs targets for diverse anthropogenic activities, estuaries are reservoirs for a variety of pollutants. Recent studies showed that sediments from a Portuguese Estuary were cytotoxic and genotoxic in a human liver cell line and in local aquatic species, possibly due to the presence of PAHs and metals. However, the extrapolation of ecological risk to risk to human health is difficult and in vivo studies are crucia...
HERA - Environmental Risk Assessment of a contaminated estuarine environment: a...
Martinho, Ana Paula; Rodrigo, Ana; Vicente, Ana; Machado, Ausenda; Dias, Carlos Matias; Guiomar, Carla Sofia; Gonçalves, Cátia; Paixão, EleonoraSado River estuary is located in the west coast of Portugal. Previous environmental studies identified industrial contamination, non-point anthropogenic sources and contamination coming from the river, all promoting accumulation of polluted sediments with known impacts on the ecological system. Surrounding human populations have intense economic fishery activities. Together with agriculture, estuary fishing pro...
Evaluation of Genotoxicity of Sediments from the Sado-River Estuary Using Solve...
Vicente, Ana Margarida; Sacadura, Joana; Pinto, Miguel; Louro, Henriqueta; Costa, Pedro Manuel; Lavinha, João; Caeiro, Sandra; Silva, Maria JoãoLocated in the western coast of Portugal, our case study, the river Sado Estuary, is affected by various sources of pollution, such as heavy-industry, urbanism, mining, agriculture and maritime traffic. Recent studies showed that sediment samples were contaminated with a mixture of different groups of contaminants related to the different anthropogenic pressures along the estuary. The present study aims to asse...
DNA and Chromosome Damaging Effects in Mice Exposed to an Estuary Sediment Extract
Pinto, Miguel; Sacadura, Joana; Louro, Henriqueta; Costa, Pedro Manuel; Lavinha, João; Silva, Maria JoãoPrevious studies have shown that an extract of a sediment sample collected in a fishing area of Sado Estuary, impacted by the urban and industrial pollution from the city of Setúbal, was able to induce cytotoxicity and genotoxicity in a human cell line (HepG2) and in local aquatic species, probably due to the presence of PAHs and metals. However, the assessment of the potential hazard of those contaminants to h...
Genotoxicity and oxidative stress induced by sediments from the Sado Estuary an...
Pinto, Miguel; Sacadura, Joana; Louro, Henriqueta; Costa, Pedro Manuel; Costa, Maria Helena; Caeiro, Sandra; Lavinha, João; Silva, Maria JoãoThe Sado Estuary is affected by various sources of pollution, such heavy-industry, urbanism, mining, agriculture and maritime traffic and sizable amounts of organic and inorganic contaminants were identified in the sediments. These compounds can be accumulated in the edible parts of estuarine species and agricultural products, thus entering the human food chain and posing a public health problem. This study had...