The mononuclear phagocyte system comprises a network of circulating monocytes and dendritic cells (DCs), and "histiocytes" (tissue-resident macrophages and DCs) that are derived in part from blood-borne monocytes and DCs. The capacity of circulating monocytes and DCs to function as the body's first-line defense against offending pathogens greatly depends on their ability to egress the bloodstream and infiltrate...
SFRH/BD/100970/2014 This work was supported by the LPCC/Pfizer2011 and Portuguese Foundation for Science and Technology (FCT) - SFRH/BD/100970/2014 (MAC) and Premio Santander/ Totta - UNL, Bluepharma/UC (PAV), by the National Institutes of Health, in particular, the National Heart Lung Blood Institute (NHLBI) Program of Excellence in Glycosciences (PEG) grant PO1 HL107146 (RS) and by the GlycoCan Marie Curie Ac...