4 documents found, page 1 of 1
Efeito Cardioprotetor da Suplementação Materna com Resveratrol sobre a Toxicida...
Brito,Verônica Bidinotto; Nascimento,Leopoldo Vinicius Martins; Moura,Dinara Jaqueline; Saffi,JeniferResumo Fundamento A doxorrubicina (DOX) é frequentemente usada para tratar muitos tipos de cânceres, apesar da cardiotoxicidade dose-dependente. Como alternativa, o resveratrol é um polifenol que tem demonstrado efeitos cardioprotetores em vários modelos de disfunção cardíaca. Objetivo Este estudo investigou se o tratamento com resveratrol em ratas gestantes protege contra toxicidade induzida por doxorrubicina ...
Potent antileukemic action of naphthoquinoidal compounds: evidence for an intri...
Cavalcanti,Bruno C.; Cabral,Igor O.; Rodrigues,Felipe A. R.; Barros,Francisco W. A.; Rocha,Danilo D.; Magalhães,Hemerson I. F.; Moura,Dinara J.The current study describes that nor-β-lapachone and its arylamino derivatives, iodinated and methylated naphthoquinones and nor-β-lapachone-based 1,2,3-triazoles exhibited pronounced cytotoxic effects against four human leukemia cell lines (HL-60, K562, Molt-4 and Jurkat). Nor-β-lapachones arylamino substituted with potent activity were identified, revealing themselves as potential prototypes against tumor cel...
Chemical constituents and evaluation of cytotoxic and antifungal activity of La...
Medeiros,Lídia B. P.; Rocha,Márcio dos S.; Lima,Sidney G. de; Sousa Júnior,Gustavo R. de; Citó,Antônia M. das G. L.; Silva,Davi da; Lopes,José A. D.The essential oil (EO) of aerial parts of Lantana camara L., Verbenaceae, from Simões, Piaui, Northeast of Brazil, were obtained by hydrodistillation and analyzed by GC-FID and GC-MS techniques. In total, 68 compounds were identified. The most representative compounds of the oil were mono and sesquiterpenes. The main compounds found in the oil of the leaves in different months were β-caryophyllene (10.5%, in Ju...
Evaluation of effects of dichloromethane fraction from Platonia insignis on pil...
Costa Júnior,Joaquim S. da; Ferraz,Alexandre de B. F.; Feitosa,Chistiane Mendes; Citó,Antonia Maria das Graças Lopes; Saffi,JeniferThe objective of present study was to evaluate the antioxidant and anticonvulsant activities of dichloromethane fraction (DMF) from Platonia insignis Mart., Clusiaceae. The DMF from P. insignis (2 mg/kg) was tested by intraperitoneal (i.p.) to evaluate effects on lipid peroxidation level, nitrite formation, as well as on locomotor and anticonvulsant activities. Wistar rats were treated with, (saline/Tween 80 0....