4 documents found, page 1 of 1
Recombinant cathepsins B and L promote α-synuclein clearance and restore lysoso...
Balta, Denise; Varghese, Anish; Prieto Huarcaya, Susy; Di Spiezio, Alessandro; R. A. Marques, André; Akdaş, Enes Yağız; Tabakacilar, Doğa; Drobny, AliceFunding Information: Open Access funding enabled and organized by Projekt DEAL. This work was supported by the Deutsche Forschungsgemeinschaft (DFG), Bonn, German: SFB877, project B11, grant number: 125440785, GRK2162, grant number: 270949263 and CRU5024 grant number: 505539112, and the Interdisciplinary Center for Clinical Research (IZKF) at the University Hospital of the University of Erlangen-Nuremberg (Joch...
Cathepsin D
Gallwitz, Lisa; Schmidt, Lina; Marques, André R.A.; Tholey, Andreas; Cassidy, Liam; Ulku, Irem; Multhaup, Gerhard; Di Spiezio, Alessandro; Saftig, PaulFunding Information: This work was supported in part by the Deutsche Forschungsgemeinschaft ( SFB877 , A3 and Z2) and the Canadian Institutes of Health Research – CIHR (to GM). Publisher Copyright: © 2022; Proteolysis catalyzed by the major lysosomal aspartyl protease cathepsin-D (CTSD) appears to be of pivotal importance for proteostasis within the central nervous system and in neurodegeneration. Neuronal Cero...
Recombinant pro-CTSD (cathepsin D) enhances SNCA/α-Synuclein degradation in α-S...
Prieto Huarcaya, Susy; Drobny, Alice; Marques, André R A; Di Spiezio, Alessandro; Dobert, Jan Philipp; Balta, Denise; Werner, Christian; Rizo, TaniaParkinson disease (PD) is a neurodegenerative disorder characterized by the abnormal intracellular accumulation of SNCA/α-synuclein. While the exact mechanisms underlying SNCA pathology are not fully understood, increasing evidence suggests the involvement of autophagic as well as lysosomal deficiencies. Because CTSD (cathepsin D) has been proposed to be the major lysosomal protease involved in SNCA degradation...
Erratum to
Klionsky, Daniel J.; Abdelmohsen, Kotb; Abe, Akihisa; Abedin, Md Joynal; Abeliovich, Hagai; Arozena, Abraham Acevedo; Adachi, Hiroaki