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Brain Iron Deficiency Changes the Stoichiometry of Adenosine Receptor Subtypes ...
Rodrigues, Matilde S.; Ferreira, Samira G.; Quiroz, César; Earley, Christopher J; García-Borreguero, Diego; Cunha, Rodrigo A.; Ciruela, FranciscoBrain iron deficiency (BID) constitutes a primary pathophysiological mechanism in restless legs syndrome (RLS). BID in rodents has been widely used as an animal model of RLS, since it recapitulates key neurochemical changes reported in RLS patients and shows an RLS-like behavioral phenotype. Previous studies with the BID-rodent model of RLS demonstrated increased sensitivity of cortical pyramidal cells to relea...
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, RamónIt has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved in the modulation of striatal excitatory neurotransmission. Previous studies have demonstrated the existence of A2AR-CB1R heteromers in artificial cell systems. A dependence of A2AR s...
Control of glutamate release by complexes of adenosine and cannabinoid receptors
Köfalvi, Attila; Moreno, Estefanía; Cordomí, Arnau; Cai, Ning-Sheng; Fernández-Dueñas, Victor; Ferreira, Samira G.; Guixà-González, RamónBackground: It has been hypothesized that heteromers of adenosine A2A receptors (A2AR) and cannabinoid CB1 receptors (CB1R) localized in glutamatergic nerve terminals mediate the integration of adenosine and endocannabinoid signaling involved in the modulation of striatal excitatory neurotransmission. Previous studies have demonstrated the existence of A2AR-CB1R heteromers in artificial cell systems. A dependen...
Glutamate-induced and NMDA receptor-mediated neurodegeneration entails P2Y1 rec...
Simões, Ana P.; Silva, Carla G.; Marques, Joana M.; Pochmann, Daniela; Porciúncula, Lisiane O.; Ferreira, Sofia; Oses, Jean P.; Beleza, Rui de O.Despite the characteristic etiologies and phenotypes, different brain disorders rely on common pathogenic events. Glutamate-induced neurotoxicity is a pathogenic event shared by different brain disorders. Another event occurring in different brain pathological conditions is the increase of the extracellular ATP levels, which is now recognized as a danger and harmful signal in the brain, as heralded by the abili...
Neuronal Adenosine A2A Receptors Are Critical Mediators of Neurodegeneration Tr...
Canas, Paula M.; Porciúncula, Lisiane O.; Simões, Ana Patrícia; Augusto, Elisabete de Oliveira; Silva, Henrique B.; Machado, Nuno J.; Gonçalves, NélioNeurodegeneration is a process transversal to neuropsychiatric diseases and the understanding of its mechanisms should allow devising strategies to prevent this irreversible step in brain diseases. Neurodegeneration caused by seizures is a critical step in the aggravation of temporal lobe epilepsy, but its mechanisms remain undetermined. Convulsions trigger an elevation of extracellular adenosine and upregulate...
Adenosine A2A Receptors in the Rat Prelimbic Medial Prefrontal Cortex Control D...
Leffa, Douglas T; Pandolfo, Pablo; Gonçalves, Nélio; Machado, Nuno J.; de Souza, Carolina M; Real, Joana I.; Silva, Antonio C.; Silva, Henrique B.Adenosine A2A receptors (A2ARs) were recently described to control synaptic plasticity and network activity in the prefrontal cortex (PFC). We now probed the role of these PFC A2AR by evaluating the behavioral performance (locomotor activity, anxiety-related behavior, cost-benefit decision making and working memory) of rats upon downregulation of A2AR selectively in the prelimbic medial PFC (PLmPFC) via viral s...
Behavioral phenotyping of Parkin-deficient mice: looking for early preclinical ...
Rial, Daniel; Castro, Adalberto A.; Machado, Nuno J.; Garção, Pedro; Gonçalves, Francisco Q.; Silva, Henrique B.; Tomé, Ângelo R.; Köfalvi, AttilaThere is considerable evidence showing that the neurodegenerative processes that lead to sporadic Parkinson's disease (PD) begin many years before the appearance of the characteristic motor symptoms. Neuropsychiatric, sensorial and cognitive deficits are recognized as early non-motor manifestations of PD, and are not attenuated by the current anti-parkinsonian therapy. Although loss-of-function mutations in the...
Diabetes induces early transient changes in the content of vesicular transporte...
Baptista, Filipa I.; Gaspar, Joana M.; Cristóvão, Armando; Santos, Paulo F.; Köfalvi, Attila; Ambrósio, António F.Diabetes induces changes in neurotransmitter release in central nervous system, which depend on the type of neurotransmitter and region studied. In this study, we evaluated the effect of diabetes (two and eight weeks duration) on basal and evoked release of [14C]glutamate and [3H]GABA in hippocampal and retinal synaptosomes. We also analyzed the effect of diabetes on the protein content of vesicular glutamate a...
N-acyldopamines control striatal input terminals via novel ligand-gated cation ...
Ferreira, Samira G.; Lomaglio, Tonia; Avelino, Antonio; Cruz, Francisco; Oliveira, Catarina R.; Cunha, Rodrigo A.; Köfalvi, Attilahttp://www.sciencedirect.com/science/article/B6T0C-4V3HHM3-1/2/22d594101b6927eca47e1b39b53ffcee
Modification upon aging of the density of presynaptic modulation systems in the...
Canas, Paula M.; Duarte, João M. N.; Rodrigues, Ricardo J.; Köfalvi, Attila; Cunha, Rodrigo A.Different presynaptic neuromodulation systems have been explored as possible targets to manage neurodegenerative diseases. However, most studies used young adult animals whereas neurodegenerative diseases are prevalent in the elderly. Thus, we now explored by Western blot analysis how the density of different presynaptic markers and receptors changes with aging in rat hippocampal synaptosomes (purified nerve te...