5 documents found, page 1 of 1
In a search for effective giant magnetoelectric coupling: magnetically induced ...
Martins, Pedro Libânio Abreu; Lima, Ana C.; L'vov, Victor A.; Pereira, Nélson; Sratong-on, Pimpet; Hosoda, Hideki; Chernenko, VolodymyrPoly(vinylidene fluoride-trifluoroethylene) (P(VDF-TrFE)) is a piezoelectric polymer suitable for applications in electromechanical and magnetoelectric (ME) systems. Ni-Mn-Ga alloys exhibit a giant magnetoelastic response related to their structural transformations of martensitic type, accompanied by noticeable volume changes. Together, in a thin film composite containing an ensemble of Ni-Mn-Ga particles (10 w...
Microfluidic-assisted electrospinning, an alternative to coaxial, as a controll...
Vasconcelos, Filipa; Lima, Ana C.; Bonani, Walter; Silva, Catarina S.; Reis, R. L.; Motta, Antonella; Migliaresi, Claudio; Martins, Albino; Neves, N. M.Inflammatory arthritic diseases are characterized by a persistent inflammation of the synovial tissues where tumor necrosis factor alpha (TNFα) and interleukin-6 (IL-6) pro-inflammatory cytokines are over-expressed, leading to progressive musculoskeletal disability. Methotrexate (MTX), a disease-modifying-anti-rheumatic drug (DMARD) commonly applied in their treatment, can be used in combination with biologica...
Magnetic nanoparticles for biomedical applications: From the soul of the Earth ...
Martins, Pedro Manuel Abreu; Lima, Ana C.; Ribeiro, Sylvie Oliveira; Lanceros-Méndez, S.; Martins, Pedro Libânio AbreuPrecisely engineered magnetic nanoparticles (MNPs) have been widely explored for applications including theragnostic platforms, drug delivery systems, biomaterial/device coatings, tissue engineering scaffolds, performance-enhanced therapeutic alternatives and even in SARS-CoV-2 detection strips. Such popularity is due to their unique, challenging, and tailorable physicochemical/magnetic properties. Given the wi...
Advanced treatment for arthritic diseases based on the capture and inactivation...
Lima, Ana C.; Cunha, C.; Carvalho, A.; Ferreira, H.; Neves, N. M.Arthritic diseases, such as osteoarthritis and rheumatoid arthritis, are associated with synovium inflammation (synovitis). Several pro-inflammatory cytokines, especially tumor necrosis factor-α (TNFα) and interleukins (IL), are important mediators of inflammation and articular cartilage destruction, supporting a potential possibility of anticytokine therapy in these diseases. IL-6 is one of the key regulators ...
Reassessing the Evolutionary History of the 17q21 Inversion Polymorphism
Alves, Joao M.; Lima, Ana C.; Pais, Isa A.; Amir, Nadir; Celestino, Ricardo; Piras, Giovanna; Monne, Maria; Comas, David; Heutink, Peter; Chikhi, LounèsA polymorphic inversion that lies on chromosome 17q21 comprises two major haplotype families (H1 and H2) that not only differ in orientation but also in copy-number. Although the processes driving the spread of the inversion-associated lineage (H2) in humans remain unclear, a selective advantage has been proposed for one of its subtypes. Here, we genotyped a large panel of individuals from previously overlooked...