2 documents found, page 1 of 1
Loss of Caveolin-1 in Metastasis-Associated Macrophages Drives Lung Metastatic ...
Celus, Ward; Conza, Giusy Di; Oliveira, Ana Isabel Ferreira; Ehling, Manuel; Costa, Bruno Marques; Wenes, Mathias; Mazzone, MassimilianoAlthough it is well established that tumor-associated macrophages take part in each step of cancer progression, less is known about the distinct role of the so-called metastasis-associated macrophages (MAMs) at the metastatic site. Previous studies reported that Caveolin-1 (Cav1) has both tumor-promoting and tumor-suppressive functions. However, the role of Cav1 in bone-marrow-derived cells is unknown. Here, we...
MET is required for the recruitment of anti-tumoural neutrophils
Finisguerra, Veronica; Conza, Giusy Di; Matteo, Mario Di; Serneels, Jens; Costa, Sandra Maria Araújo da; Thompson, A. A. Roger; Wauters, ElsMutations or amplification of the MET proto-oncogene are involved in the pathogenesis of several tumours, which rely on the constitutive engagement of this pathway for their growth and survival. However, MET is expressed not only by cancer cells but also by tumour-associated stromal cells, although its precise role in this compartment is not well characterized. Here we show that MET is required for neutrophil c...