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Host immune genetic variations influence the risk of developing acute myeloid l...

Sánchez-Maldonado, J. M.; Campa, D.; Springer, J.; Badiola, J.; Niazi, Y.; Moñiz-Díez, A.; Hernández-Mohedo, F.; González-Sierra, P.; Ter Horst, R.

The purpose of this study was to conduct a two-stage case control association study including 654 acute myeloid leukaemia (AML) patients and 3477 controls ascertained through the NuCLEAR consortium to evaluate the effect of 27 immune-related single nucleotide polymorphisms (SNPs) on AML risk. In a pooled analysis of cohort studies, we found that carriers of the IL13rs1295686A/A genotype had an increased risk of...


Conflicting Climate Change Frames in a Global Field of Media Discourse

Broadbent, J.; Sonnett, J.; Botetzagias, I.; Carson, M.; Carvalho, A.; Chien, Y.-J.; Edling, C.; Fisher, D.; Giouzepas, G.; Haluza-DeLay, R.

Reducing global emissions will require a global cosmopolitan culture built from detailed attention to conflicting national climate change frames (interpretations) in media discourse. The authors analyze the global field of media climate change discourse using 17 diverse cases and 131 frames. They find four main conflicting dimensions of difference: validity of climate science, scale of ecological risk, scale of...


Polymorphisms in xenobiotic transporters ABCB1, ABCG2, ABCC2, ABCC1, ABCC3 and ...

Martino, A.; Campa, D.; Buda, G.; Sainz, J.; GarcIa Sanz, R.; Jamroziak, K.; Reis, R. M.; Weinhold, N.; Jurado, M.; Rıos, R.; Szemraj-Rogucka, Zofia

Multiple myeloma (MM) is a hematological neoplasm that arises from a single clone of malignant plasma cells in the bone marrow. In Europe, 4.6/100 000 males and 3.2/100 000 females every year develop MM, with a median age at diagnosis around 60 years.


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