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Himanthalia elongata: An overview of its chemical composition and health-relate...
Catarino, Marcelo D.; Circuncisão, Ana R.; Silva, Sónia; Pinto, Diana; Pereira, Olívia R.; Cardoso, Susana M.Himanthalia elongata, commonly known as sea spaghetti, is a brown seaweed found along the Atlantic coasts of Europe, particularly in regions such as Ireland, France, and the United Kingdom, where it is considered a delicacy and is commonly used in salads, soups, and as a pasta substitute. It is renowned for its impressive nutritional profile and potential health benefits, offering a significant amount of dietar...
Towards the Valorization of Elderberry By-Product: Recovery and Use of Natural ...
Neves, Cláudia M. B.; Fogeiro, Élia; Cardoso, Susana M.; Gonçalves, Fernando Jorge; Pinto, António; Ferreira Wessel, DulcineiaOne of the food industry’s greatest challenges is to find natural ingredients capable of conferring antioxidant and color properties. In addition, the agri-food industry generates by-products that are often treated as waste, despite their abundance of phytochemicals that can be recovered and used as food ingredients. This study explores the potential of elderberry pomace, an industrial by-product of juice proce...
Exploring the fate of phlorotannins from Laminaria digitata across the gastroin...
Catarino, Marcelo D.; García, Carlos J.; García-Villalba, Rocío; Silva, Artur M. S.; Campos, Débora A.; Pintado, Maria Manuela; Neves, BrunoPhlorotannins are phenolic compounds exclusive from brown macroalgae endowed with promising bioactive properties. However, considering that diet is their main route of entrance to our system, gastrointestinal digestion might affect such bioactive properties. Here, phlorotannin extracts obtained from Laminaria digitata were submitted to simulated gastrointestinal digestion to evaluate its impact on their antioxi...
Phototrophic Colonization in Dolomitic Limestone: Comparison between Single vs ...
Soares, Fabiana; Trovão, João; Tiago, Igor; Cardoso, Susana M.; Gil, Francisco; Catarino, Lídia G.; Portugal, AntónioPhototrophic organisms, such as microalgae and cyanobacteria, are known to be major contributors to stone decay. The purpose of this study was to assess the dolomitic limestone colonization by phototrophic organisms, using single vs artificial multispecies, under laboratory conditions. To achieve this aim, dolomitic limestone blocks were inoculated with single phototrophic species previously collected from the ...
Phenolic compounds contribution to portuguese propolis anti-melanoma activity
Caetano, Ana Rita; Oliveira, Rafaela Dias; Celeiro, Sónia Pires; Freitas, Ana Sofia; Cardoso, Susana M.; Gonçalves, M. Sameiro T.; Baltazar, FátimaMelanoma is the deadliest type of skin cancer, with about 61,000 deaths annually worldwide. Late diagnosis increases mortality rates due to melanoma’s capacity to metastasise rapidly and patients’ resistance to the available conventional therapies. Consequently, the interest in natural products as a strategy for drug discovery has been emerging. Propolis, a natural product produced by bees, has several biologic...
Comparative methods to evaluate the antioxidant capacity of propolis: an attemp...
Paula, Vanessa B.; Estevinho, Leticia M.; Cardoso, Susana M.; Dias, L.G.Propolis is a natural product produced by bees that contains a complex mixture of compounds, including phenolic compounds and flavonoids. These compounds contribute to its biological activities, such as antioxidant capacity. This study analysed the pollen profile, total phenolic content (TPC), antioxidant properties, and phenolic compound profile of four propolis samples from Portugal. The total phenolic compou...
Propolis efficacy: the quest for eco-friendly solvents
Freitas, Ana Sofia; Cunha, Ana; Parpot, Pier; Cardoso, Susana M.; Oliveira, Rui Pedro Soares de; Almeida Aguiar, CristinaPropolis, a natural product made by bees with resins and balsams, is known for its complex chemical composition and remarkable bioactivities. In this study, propolis extraction was studied seeking extracts with strong bioactivities using less orthodox solvents, with some derived from apiary products. For that, a propolis sample collected from Gerês apiary in 2018 (G18) was extracted by maceration with six diffe...
Portuguese propolis antitumoral activity in melanoma involves ROS production an...
Oliveira, Rafaela Dias; Celeiro, Sónia Pires; Barbosa-Matos, Catarina; Freitas, Ana Sofia; Cardoso, Susana M.; Viana-Pereira, MartaMelanoma is the most aggressive and life-threatening skin cancer type. The melanoma genome is the most frequently mutated, with the <i>BRAF</i> mutation present in 40–60% of melanoma cases. <i>BRAF</i>-mutated melanomas are characterized by a higher aggressiveness and progression. Adjuvant targeted treatments, such as BRAF and MEK inhibitors, are added to surgical excision in <i>BRAF</i>-mutated metastatic mela...
Overview of phlorotannins’ constituents in Fucales
Catarino, Marcelo D.; Pires, Sónia M. G.; Silva, Sónia; Costa, Filipa; Braga, Susana S.; Pinto, Diana C. G. A.; Silva, Artur M. S.; Cardoso, Susana M.Fucales are an order within the Phaeophyceae that include most of the common littoral seaweeds in temperate and subtropical coastal regions. Many species of this order have long been a part of human culture with applications as food, feedand remedies in folk medicine. Apart from their high nutritional value, these seaweeds are also a well-known reservoir of multiple bioactive compounds with great industrial int...
Selective cytotoxicity of Portuguese propolis ethyl acetate fraction towards re...
Freitas, Ana Sofia; Costa, Marta Sílvia Freitas; Pontes, Olívia; Seidel, Veronique; Proença, M. Fernanda R. P.; Cardoso, Susana M.Renal cell carcinoma is the most lethal cancer of the urological system due to late diagnosis and treatment resistance. Propolis, a beehive product, is a valuable natural source of compounds with bioactivities and may be a beneficial addition to current anticancer treatments. A Portuguese propolis sample, its fractions (<i>n</i>-hexane, ethyl acetate, <i>n</i>-butanol and water) and three subfractions (<b>P1</b...