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Risk Calculators in Bipolar Disorder: A Systematic Review

Ribeiro, Joana Silva; Pereira, Daniela; Salagre, Estela; Coroa, Manuel; Santos Oliveira, Pedro; Santos, Vítor; Madeira, Nuno; Grande, Iria

Introduction: Early recognition of bipolar disorder improves the prognosis and decreases the burden of the disease. However, there is a significant delay in diagnosis. Multiple risk factors for bipolar disorder have been identified and a population at high-risk for the disorder has been more precisely defined. These advances have allowed the development of risk calculators to predict individual risk of conversi...


Blockade of the angiotensin system improves mental health domain of quality of ...

Brownstein, Daniel J.; Salagre, Estela; Köhler, Cristiano; Stubbs, Brendon; Vian, João; Pereira, Ciria; Chavarria, Victor; Karmakar, Chandan

Objective: It is unclear whether blockade of the angiotensin system has effects on mental health. Our objective was to determine the impact of angiotensin converting enzyme inhibitors and angiotensin II type 1 receptor (AT1R) blockers on mental health domain of quality of life. Study design: Meta-analysis of published literature. Data sources: PubMed and clinicaltrials.gov databases. The last search was conduct...


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