6 documents found, page 1 of 1
Molecular mechanisms of ischemia and glutamate excitotoxicity
Neves, Diogo; Salazar, Ivan L.; Almeida, Ramiro D.; Silva, Raquel M.Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs). Excitotoxicity is common to several chronic disorders of the Central Nervous System (CNS) and is considered the primary mechanism...
Molecular mechanisms of ischemia and glutamate excitotoxicity
Neves, Diogo; Salazar, Ivan L.; Almeida, Ramiro D.; Silva, Raquel M.Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs). Excitotoxicity is common to several chronic disorders of the Central Nervous System (CNS) and is considered the primary mechanism...
Molecular mechanisms of ischemia and glutamate excitotoxicity
Neves, Diogo; Salazar, Ivan L.; Almeida, Ramiro D.; Silva, Raquel M.Excitotoxicity is classically defined as the neuronal damage caused by the excessive release of glutamate, and subsequent activation of excitatory plasma membrane receptors. In the mammalian brain, this phenomenon is mainly driven by excessive activation of glutamate receptors (GRs). Excitotoxicity is common to several chronic disorders of the Central Nervous System (CNS) and is considered the primary mechanism...
Posttranslational modifications of proteins are key features in the identificat...
Salazar, Ivan L.; Lourenço, Ana S. T.; Manadas, Bruno; Baldeiras, Inês; Ferreira, Cláudia; Teixeira, Anabela Claro; Mendes, Vera M.; Novo, Ana MargaridaMultiple sclerosis is an inflammatory and degenerative disease of the central nervous system (CNS) characterized by demyelination and concomitant axonal loss. The lack of a single specific test, and the similarity to other inflammatory diseases of the central nervous system, makes it difficult to have a clear diagnosis of multiple sclerosis. Therefore, laboratory tests that allows a clear and definite diagnosis...
BDNF-Live-Exon-Visualization (BLEV) Allows Differential Detection of BDNF Trans...
Singer, Wibke; Manthey, Marie; Panford-Walsh, Rama; Matt, Lucas; Geisler, Hyun-Soon; Passeri, Eleonora; Baj, Gabriele; Tongiorgi, Enrico; Leal, GracianoBdnf exon-IV and exon-VI transcripts are driven by neuronal activity and are involved in pathologies related to sleep, fear or memory disorders. However, how their differential transcription translates activity changes into long-lasting network changes is elusive. Aiming to trace specifically the network controlled by exon-IV and -VI derived BDNF during activity-dependent plasticity changes, we generated a tran...
Role of the ubiquitin–proteasome system in brain ischemia: Friend or foe?
Caldeira, Margarida V.; Salazar, Ivan L.; Cursio, Michele; Canzoniero, Lorella M. T.; Duarte, Carlos B.The ubiquitin–proteasome system (UPS) is a catalytic machinery that targets numerous cellular proteins for degradation, thus being essential to control a wide range of basic cellular processes and cell survival. Degradation of intracellular proteins via the UPS is a tightly regulated process initiated by tagging a target protein with a specific ubiquitin chain. Neurons are particularly vulnerable to any change ...