2 documents found, page 1 of 1
Disclosing azole resistance mechanisms in resistant Candida glabrata strains en...
Salazar, Sara B.; Pinheiro, Maria Joana F.; Sotti-Novais, Danielle; Soares, Ana; Lopes, Maria M.; Ferreira, Teresa; Rodrigues, Vitória; Fernandes, FábioThe pathogenic yeast Candida glabrata is intrinsically resilient to azoles and rapidly acquires resistance to these antifungals, in vitro and in vivo. In most cases azole-resistant C. glabrata clinical strains encode hyperactive CgPdr1 variants, however, resistant strains encoding wild-type CgPDR1 alleles have also been isolated, although remaining to be disclosed the underlying resistance mechanism. In this st...
The CgHaa1-regulon mediates response and tolerance to acetic acid stress in the...
Bernardo, Ruben T.; Cunha, Diana V.; Wang, Can; Pereira, L. P.; Silva, Sónia Carina; Salazar, Sara B.; Schröder, Markus S.; Okamoto, MichiyoTo thrive in the acidic vaginal tract C. glabrata has to cope with high concentrations of acetic acid. The mechanisms underlying C. glabrata tolerance to acetic acid at low pH remain largely uncharacterized. In this work it is demonstrated the essential role of the CgHaa1 transcription factor (encoded by ORF CAGL0L09339g) in the response and tolerance of C. glabrata to acetic acid. Transcriptomic analysis showe...