Made available in DSpace on 2018-12-11T17:24:11Z (GMT). No. of bitstreams: 0 Previous issue date: 2016-02-18; Methotrexate (MTX) is an immunosuppressive drug for systemic use in the treatment of skin diseases, however, MTX presents a number of side effects, such as hepatotoxicity. To overcome this limitation, this study developed skin MTX delivery surfactant systems, such as a microemulsion (ME) and a liquid cr...