85 documents found, page 1 of 9
The role of the erythrocyte on humans with COVID-19
Saldanha, CarlotaCOVID-19 is a new out-breaking human disease characterized by a severe acute respiratory syndrome caused by Coronavirus 2 (SARS-CoV-2). A pandemic state was swiftly declared by the World Health Organization due its fast transmissibility and huge human mortality index. After a brief introduction to the COVID -19 disease such as the ways of virus transportation inside the human body, the aim of this revision is t...
Endothelial cell plasma membrane biomechanics mediates effects of pro-inflammat...
Barvitenko, Nadezhda; Ashrafuzzaman, Mohammad; Lawen, Alfons; Skverchinskaya, Elisaveta; Saldanha, Carlota; Manca, Alessia; Uras, GiuseppeChronic low-grade vascular inflammation and endothelial dysfunction significantly contribute to the pathogenesis of cardiovascular diseases. In endothelial cells (ECs), anti-inflammatory or pro-inflammatory signaling can be induced by different patterns of the fluid shear stress (SS) exerted by blood flow on ECs. Laminar blood flow with high magnitude is anti-inflammatory, while disturbed flow and laminar flow ...
Contribution of technology to human cell properties
Saldanha, CarlotaAfter explaining the meaning of SARS-CoV2, the protection rules for the disease caused by this virus are described in order to eradicate the resulting pandemic. Methods to differentiate asymptomatic from symptomatic patients will be mentioned. Human lungs, heart, kidney, endothelium and erythrocyte have specific binding sites for the SARS-CoV2. The aim of this opinion was to highlight some new disposable techno...
Two motors and one spring: hypothetic roles of non-muscle Myosin II and submemb...
Barvitenko, Nadezhda; Aslam, Muhammad; Lawen, Alfons; Saldanha, Carlota; Skverchinskaya, Elisaveta; Uras, Giuseppe; Manca, Alessia; Pantaleo, AntonellaChanges in plasma membrane curvature and intracellular ionic strength are two key features of cell volume perturbations. In this hypothesis we present a model of the responsible molecular apparatus which is assembled of two molecular motors [non-muscle myosin II (NMMII) and protrusive actin polymerization], a spring [a complex between the plasma membrane (PM) and the submembrane actin-based cytoskeleton (smACSK...
Pleiotropic and potentially beneficial effects of reactive oxygen species on th...
Barvitenko, Nadezhda; Skverchinskaya, Elisaveta; Lawen, Alfons; Matteucci, Elena; Saldanha, Carlota; Uras, Giuseppe; Manca, Alessia; Aslam, MuhammadEndothelial cells (ECs) are exposed to molecular dioxygen and its derivative reactive oxygen species (ROS). ROS are now well established as important signaling messengers. Excessive production of ROS, however, results in oxidative stress, a significant contributor to the development of numerous diseases. Here, we analyze the experimental data and theoretical concepts concerning positive pro-survival effects of ...
Therapeutic approach for Covid-19 patients
Saldanha, CarlotaThe biochemical effects of hydroxychloroquine, ivermectin, azithromycin molecules, and the zinc cation on functional properties of human erythrocyte will be presented. Among a wide range of therapeutically applications attributed to hydroxycloroquine the anti-inflammatory role will be herein highlight as well as for the azithromycin. The intervention of the ivermectin molecules into cell abortion mechanism of t...
Hemorheology, microcirculation and macrocirculation
Saldanha, CarlotaThe article by Cekirdekci and Bugan published in this issue of the Journal opens up new prospects for improving our knowledge of microvascular angina (MVA). Clinical characterization of MVA and coronary artery disease (CAD) shows them to be examples of endothelial dysfunction at the level of the microcirculation and macrocirculation, respectively. There is now general consensus about both coronary microcirculat...
Effects of diabetes on microcirculation and leukostasis in retinal and non-ocul...
Silva-Herdade, Ana S.; Mota-Silva, Iara; Calado, Ângelo; Saldanha, Carlota; Nguyen, Ngan-Ha; Hou, Isabella; Castanho, Miguel A. R. B.; Roy, SayonChanges in retinal microcirculation are associated with the development of diabetic retinopathy (DR). However, it is unclear whether such changes also develop in capillary beds of other non-retinal tissues. Here, we investigated microcirculatory changes involving velocity of rolling neutrophils, adherence of neutrophils, and leukostasis during development of retinal vascular lesions in diabetes in other non-ret...
Erythrocyte a target for Covid-19 infected patients
Saldanha, CarlotaThe questions about the Covid-2 and the discussion of the answers are the aim of the present opinion. Facing the great amount of knowledge centered in the field of red blood cells (RBC) or erythrocyte arise the principle for a diagnostic test with efficiency, accuracy, fast and cheap in order to differentiate the infected Covid-19 patients from those that are asymptomatic but with or without the Covid-19. Diffe...
Fibrinogen involvement in hemorheology and inflammation
Saldanha, Carlota; Silva-Herdade, Ana S.The aim of this chapter is to review the knowledge obtained from; (i) ex vivo and in vitro studies about the effects of human soluble fibrinogen molecules on blood components behavior and their effects on physiological and pathophysiological conditions, and (ii) in vitro studies conducted on experimental animal models. Ex vivo studies which demonstrated the hemorheogical participation of plasma fibrinogen and i...