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Rainfall events and daily mortality across 645 global locations: two stage time...

He, C; Breitner-Busch, S; Huber, V; Chen, K; Zhang, S; Gasparrini, A; Bell, M; Kan, H; Royé, D; Armstrong, B; Schwartz, J; Sera, F; Vicedo-Cabrera, AM

"Objective: To examine the associations between characteristics of daily rainfall (intensity, duration, and frequency) and all cause, cardiovascular, and respiratory mortality. Design: Two stage time series analysis. Setting: 645 locations across 34 countries or regions. Population: Daily mortality data, comprising a total of 109 954 744 all cause, 31 164 161 cardiovascular, and 11 817 278 respiratory deaths fr...


Seasonality of mortality under climate change: a multicountry projection study

Madaniyazi, L; Armstrong, B; Tobias, A; Mistry, MN; Bell, ML; Urban, A; Kyselý, J; Ryti, N; Cvijanovic, I; Ng, CFS; Roye, D; Vicedo-Cabrera, AM; Tong, S

Background: Climate change can directly impact temperature-related excess deaths and might subsequently change the seasonal variation in mortality. In this study, we aimed to provide a systematic and comprehensive assessment of potential future changes in the seasonal variation, or seasonality, of mortality across different climate zones. Methods: In this modelling study, we collected daily time series of mean ...


Temporal change in minimum mortality temperature under changing climate A multi...

Yang, D; Hashizume, M; Tobías, A; Honda, Y; Roye, D; Oh, J; Dang, TN; Kim, Y; Abrutzky, R; Guo, Y; Tong, S; Coelho, MDSZS; Saldiva, PHN; Lavigne, E

Background: The minimum mortality temperature (MMT) or MMT percentile (MMTP) is an indicator of population susceptibility to nonoptimum temperatures. MMT and MMTP change over time; however, the changing directions show region-wide heterogeneity. We examined the heterogeneity of temporal changes in MMT and MMTP across multiple communities and in multiple countries. Methods: Daily time-series data for mortality a...


Comparison for the effects of different components of temperature variability o...

Wen, B; Wu, Y; Guo, Y; Gasparrini, A; Tong, S; Overcenco, A; Urban, A; Schneider, A; Entezari, A; Vicedo-Cabrera, AM; Zanobetti, A; Analitis, A; Zeka, A

Background: Temperature variability (TV) is associated with increased mortality risk. However, it is still unknown whether intra-day or inter-day TV has different effects. Objectives: We aimed to assess the association of intra-day TV and inter-day TV with all-cause, cardiovascular, and respiratory mortality. Methods: We collected data on total, cardiovascular, and respiratory mortality and meteorology from 758...


Regional variation in the role of humidity on city-level heat-related mortality

Guo, Q; Mistry, MN; Zhou, X; Zhao, G; Kino, K; Wen, B; Cvijanovic, I; Yoshimura, K; Satoh, Y; Kim, Y; Ng, CFS; Vicedo-Cabrera, AM; Armstrong, B

The rising humid heat is regarded as a severe threat to human survivability, but the proper integration of humid heat into heat-health alerts is still being explored. Using state-of-the-art epidemiological and climatological datasets, we examined the association between multiple heat stress indicators (HSIs) and daily human mortality in 739 cities worldwide. Notable differences were observed in the long-term tr...


Heterogeneous impacts of mobility restrictions on air quality in the State of S...

Cirqueira, SSR; Rodrigues, PF; Branco, P; Vormittag, E; Nunes, R; Anastacio, AVB; Veras, M; Sousa, SIV; Saldiva, PHN

Air quality in the State of Sao Paulo was evaluated during the first general State plan of mobility restrictions due to the COVID-19 pandemic (24th March to May 31, 2020). Nitrogen dioxide (NO2), ozone (O-3), particulate matter PM10 and PM2.5 and sulphur dioxide (SO2) concentrations were assessed in cities of the Sao Paulo State with a monitoring station and compared to historical data. Linear regression models...


Comparison of weather station and climate reanalysis data for modelling tempera...

Mistry, MN; Schneider, R; Masselot, P; Royé, D; Armstrong, B; Kyselý, J; Orru, H; Sera, F; Tong, S; Lavigne, É; Urban, A; Madureira, J; García-León, D

Epidemiological analyses of health risks associated with non-optimal temperature are traditionally based on ground observations from weather stations that offer limited spatial and temporal coverage. Climate reanalysis represents an alternative option that provide complete spatio-temporal exposure coverage, and yet are to be systematically explored for their suitability in assessing temperature-related health r...


Associations Between Extreme Temperatures and Cardiovascular Cause-Specific Mor...

Alahmad, B; Khraishah, H; Royé, D; Vicedo-Cabrera, AM; Guo, Y; Papatheodorou, SI; Achilleos, S; Acquaotta, F; Armstrong, B; Bell, ML; Pan, SC

Background: Cardiovascular disease is the leading cause of death worldwide. Existing studies on the association between temperatures and cardiovascular deaths have been limited in geographic zones and have generally considered associations with total cardiovascular deaths rather than cause-specific cardiovascular deaths. Methods: We used unified data collection protocols within the Multi-Country Multi-City Coll...


Short term associations of ambient nitrogen dioxide with daily total, cardiovas...

Meng, X; Liu, C; Chen, R; Sera, F; Vicedo-Cabrera, AM; Milojevic, A; Guo, Y; Tong, S; Coelho, MSZS; Saldiva, PHN; Lavigne, E; Correa, PM; Ortega, NV

Objective To evaluate the short term associations between nitrogen dioxide (NO2) and total, cardiovascular, and respiratory mortality across multiple countries/regions worldwide, using a uniform analytical protocol. Design Two stage, time series approach, with overdispersed generalised linear models and multilevel meta-analysis. Setting 398 cities in 22 low to high income countries/regions. Main outcome measure...


The burden of heat-related mortality attributable to recent human-induced clima...

Vicedo-Cabrera, AM; Scovronick, N; Sera, F; Royé, D; Schneider, R; Tobias, A; Astrom, C; Guo, Y; Honda, Y; Hondula, DM; Abrutzky, R; Tong, S

Climate change affects human health; however, there have been no large-scale, systematic efforts to quantify the heat-related human health impacts that have already occurred due to climate change. Here, we use empirical data from 732 locations in 43 countries to estimate the mortality burdens associated with the additional heat exposure that has resulted from recent human-induced warming, during the period 1991...


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