40 documents found, page 1 of 4
Nanotechnology-Based Strategies for Berberine Delivery System in Cancer Treatme...
Iqbal, MJ; Quispe, C; Javed, Z; Sadia, H; Qadri, QR; Raza, S; Salehi, B; Martins, N; Abdulwanis Mohamed, Z; Sani Jaafaru, M; Abdull Razis, AFCancer is a multifactorial disease characterized by complex molecular landscape and altered cell pathways that results in an abnormal cell growth. Natural compounds are target-specific and pose a limited cytotoxicity; therefore, can aid in the development of new therapeutic interventions for the treatment of this versatile disease. Berberine is a member of the protoberberine alkaloids family, mainly present in ...
Phytosterols: From Preclinical Evidence to Potential Clinical Applications
Salehi, B; Quispe, C; Sharifi-Rad, J; Martins, N; Nigam, M; Mishra, AP; Konovalov, DA; Orobinskaya, V; Abu-Reidah, IM; Zam, W; Sharopov, F; Venneri, TPhytosterols (PSs) are plant-originated steroids. Over 250 PSs have been isolated, and each plant species contains a characteristic phytosterol composition. A wide number of studies have reported remarkable pharmacological effects of PSs, acting as chemopreventive, anti-inflammatory, antioxidant, antidiabetic, and antiatherosclerotic agents. However, PS bioavailability is a key issue, as it can be influenced by...
Targeting androgen receptor signaling with MicroRNAs and Curcumin: a promising ...
Javed, Z; Khan, K; Rasheed, A; Sadia, H; Shahwani, MN; Irshad, A; Raza, S; Salehi, B; Sharifi-Rad, J; Suleria, HAR; Martins, N; Quispe, CProstate cancer (PC) is a multifactorial disease characterized by the abrogation of androgen receptor signaling. Advancement in microbiology techniques has highlighted the significant role of microRNAs (miRNAs) in the progression of PC cells from an androgen-dependent to an androgen-independent state. At that stage, prostate tumors also fail to respond to currently practiced hormone therapies. So, studies in re...
Therapeutic Potential of Quercetin: New Insights and Perspectives for Human Health
Salehi, B; Machin, L; Monzote, L; Sharifi-Rad, J; Ezzat, SM; Salem, MA; Merghany, RM; El Mahdy, NM; Klllç, CS; Sytar, O; Sharifi-Rad, M; Sharopov, FQuercetin (Que) and its derivatives are naturally occurring phytochemicals with promising bioactive effects. The antidiabetic, anti-inflammatory, antioxidant, antimicrobial, anti-Alzheimer's, antiarthritic, cardiovascular, and wound-healing effects of Que have been extensively investigated, as well as its anticancer activity against different cancer cell lines has been recently reported. Que and its derivatives...
Curcumin’s nanomedicine formulations for therapeutic application in neurologica...
Salehi, B; Calina, D; Docea, AO; Koirala, N; Aryal, S; Lombardo, D; Pasqua, L; Taheri, Y; Castillo, CMS; Martorell, M; Martins, N; Iriti, MThe brain is the body’s control center, so when a disease affects it, the outcomes are devastating. Alzheimer’s and Parkinson’s disease, and multiple sclerosis are brain diseases that cause a large number of human deaths worldwide. Curcumin has demonstrated beneficial effects on brain health through several mechanisms such as antioxidant, amyloid ß-binding, anti-inflammatory, tau inhibition, metal chelation, ne...
Antioxidant, Antimicrobial, and Anticancer Effects of Anacardium Plants: An Eth...
Salehi, B; Gültekin-Özgüven, M; Kirkin, C; Özçelik, B; Morais-Braga, MFB; Carneiro, JNP; Bezerra, CF; Silva, TGd; Coutinho, HDM; Amina, B; Armstrong, LAnacardium plants have received increasing recognition due to its nutritional and biological properties. A number of secondary metabolites are present in its leaves, fruits, and other parts of the plant. Among the diverse Anacardium plants' bioactive effects, their antioxidant, antimicrobial, and anticancer activities comprise those that have gained more attention. Thus, the present article aims to review the A...
Therapeutic applications of curcumin nanomedicine formulations in cardiovascula...
Salehi, B; Del Prado-Audelo, ML; Cortés, H; Leyva-gómez, G; Stojanovic-radic, Z; Singh, YD; Patra, JK; Das, G; Martins, N; Martorell, M; Sharifi-rad, MCardiovascular diseases (CVD) compromises a group of heart and blood vessels disorders with high impact on human health and wellbeing. Curcumin (CUR) have demonstrated beneficial effects on these group of diseases that represent a global burden with a prevalence that continues increasing progressively. Pre- and clinical studies have demonstrated the CUR effects in CVD through its anti-hypercholesterolemic and a...
Myricetin bioactive effects: Moving from preclinical evidence to potential clin...
Taheri, Y; Suleria, HAR; Martins, N; Sytar, O; Beyatli, A; Yeskaliyeva, B; Seitimova, G; Salehi, B; Semwal, P; Painuli, S; Kumar, A; Azzini, ESeveral flavonoids have been recognized as nutraceuticals, and myricetin is a good example. Myricetin is commonly found in plants and their antimicrobial and antioxidant activities is well demonstrated. One of its beneficial biological effects is the neuroprotective activity, showing preclinical activities on Alzheimer, Parkinson, and Huntington diseases, and even in amyotrophic lateral sclerosis. Also, myricet...
Avocado–Soybean unsaponifiables: A panoply of potentialities to be exploited
Salehi, B; Rescigno, A; Dettori, T; Calina, D; Docea, AO; Singh, L; Cebeci, F; Özçelik, B; Bhia, M; Beirami, AD; Sharifi-Rad, J; Sharopov, F; Cho, WCAvocado and soybean unsaponifiables (ASU) constitute vegetable extracts made from fruits and seeds of avocado and soybean oil. Characterized by its potent anti-inflammatory effects, this ASU mixture is recommended to act as an adjuvant treatment for osteoarthritic pain and slow-acting symptomatic treatment of hip and knee osteoarthritis; autoimmune diseases; diffuse scleroderma and scleroderma-like states (e.g....
Turmeric and Its Major Compound Curcumin on Health: Bioactive Effects and Safet...
Sharifi-Rad, J; Rayess, YE; Rizk, AA; Sadaka, C; Zgheib, R; Zam, W; Sestito, S; Rapposelli, S; Neffe-Skocinska, K; Zielinska, D; Salehi, B; Setzer, WNCurcumin, a yellow polyphenolic pigment from the Curcuma longa L. (turmeric) rhizome, has been used for centuries for culinary and food coloring purposes, and as an ingredient for various medicinal preparations, widely used in Ayurveda and Chinese medicine. In recent decades, their biological activities have been extensively studied. Thus, this review aims to offer an in-depth discussion of curcumin application...