Ru(II)-thymine complex [Ru(PPh3)2(Thy)(bipy)]PF6 (where PPh3 = triphenylphosphine, Thy = thyminate and bipy = 2,2′-bipyridine) is a potent cytotoxic agent with ability to bind to DNA, inducing caspase-mediated apoptosis in leukemia cells. In this study, we investigated the mechanism underlying the cell death induction by Ru(II)-thymine complex in human colon carcinoma HCT116 cells, as well as its effect in xeno...
Ruthenium(II) complexes with 6-methyl-2-thiouracil cis-[Ru(6m2tu)2(PPh3)2] (1) and [Ru(6m2tu)2(dppb)] (2) (where PPh3 = triphenylphosphine; dppb = 1,4-bis(diphenylphosphino)butane; and 6m2tu = 6-methyl-2-thiouracil) are potent cytotoxic agents and able to bind DNA. The aim of this study was to evaluate in vitro cellular underlying mechanism and in vivo effectiveness of these ruthenium(II) complexes in human acu...
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Trabalho completo: acesso restrito, p.269–275; Submitted by Bruna Lessa (lessbruna@gmail.com) on 2012-07-06T20:23:03Z No. of bitstreams: 1 (112)fulltext.pdf: 332259 bytes, checksum: cabe5a7981bb691f423b52719e8a2f82 (MD5); Made available in DSpace on 2012-07-06T20:23:03Z (GMT). No. of bitstreams: 1 (112)fulltext.pdf: 332259 bytes, checksum: cabe5a7981bb691f423b52719e8a2f82 (MD5) Previous issue date: 2009; Kerato...