5 documents found, page 1 of 1
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Application of gold nanoparticles as radiosensitizer for metastatic prostate ca...
Soares, Sílvia; Faria, Isabel; Aires, Fátima; Monteiro, Armanda; Pinto, Gabriela; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.More than 50% of all prostate cancer (PCa) patients are treated by radiotherapy (RT). Radioresistance and cancer recurrence are two consequences of the therapy and are related to dose heterogeneity and non-selectivity between normal and tumoral cells. Gold nanoparticles (AuNPs) could be used as potential radiosensitizers to overcome these therapeutic limitations of RT. This study assessed the biological interac...
Metabolic disruption of gold nanospheres, nanostars and nanorods in human metas...
Soares, Sílvia; Pereira, Cláudia; Sousa, André P.; Oliveira, Ana Catarina; Sales, Maria Goreti; Correa-Duarte, Miguel A.; Guerreiro, Susana G.Nanomaterials offer a broad spectrum of applications in biomedicine. The shapes of gold nanoparticles could modulate tumor cell behavior. Spherical (AuNPsp), stars (AuNPst) and rods (AuNPr) shapes of polyethylene glycol coated-gold nanoparticles (AuNPs-PEG) were synthesized. Metabolic activity, cellular proliferation, and reactive oxygen species (ROS) were measured and the impact of AuNPs-PEG in metabolic enzym...
The Influence of miRNAs on Radiotherapy Treatment in Prostate Cancer - A System...
Soares, Sílvia; Guerreiro, Susana G; Cruz-Martins, Natália; Faria, Isabel; Baylina, Pilar; Sales, Maria Goreti; Correa-Duarte, Miguel AIn the last years, extensive investigation on miRNomics have shown to have great advantages in cancer personalized medicine regarding diagnosis, treatment and even clinical outcomes. Prostate cancer (PCa) is the second most common male cancer and about 50% of all PCa patients received radiotherapy (RT), despite some of them develop radioresistance. Here, we aim to provide an overview on the mechanisms of miRNA ...
Biotecnologias
Sales, Maria Goreti; Ferreira, Eugénio C.; Reis, Maria Ascensão[Excerto] Existem várias definições de Biotecnologia. Um documento da European Foundation for the Improvement of Living and Working Conditions refere a existência de 41 (quarenta e uma!) definições no seio da União Europeia. A Federação Europeia de Biotecnologia propõe a seguinte definição: “Biotecnologia é a integração das Ciências Naturais e das Ciências de Engenharia com vista à aplicação industrial de organ...