4 documents found, page 1 of 1
Synthesis and Anti-Chikungunya Virus (CHIKV) Activity of Novel 1,4-Naphthoquino...
Pacheco,Paulo A. F.; Gonzaga,Daniel T.; Cirne-Santos,Cláudio C.; Barros,Caroline S.; Gomes,Max W. L.; Gomes,Rafaela S. P.; Gonçalves,Mariana C.Chikungunya virus (CHIKV) is a re-emerging disease caused by an alphavirus of the Togaviridae family. Since its first description in 1952, the disease has spread worldwide, affecting populations in both tropical and temperate countries. To date, there is no licensed vaccine or specific pharmacological treatment. Therefore, there is an increasing urgency in developing new antiviral drugs capable of specifically ...
Antibacterial Profile in vitro and in vivo of New 1,4-Naphthoquinones Tethered ...
Gomes,Mônica P.; Correia,Eduardo M.; Gomes,Max W. L.; Santos,Claudio C. C. dos; Barros,Caroline S.; Abreu,Fernanda V. de; Antunes,Leonardo S.The cariogenic processes are mainly caused by the bacterium Streptococcus mutans (S. mutans) and consist of the demineralization of the tooth that occurs when the acid production overcomes the natural repair or if a problem occurs in the last one. In this work, we performed the synthesis of twenty-one 1,4-naphthoquinones tethered to 1,2,3-1H-triazoles (8a-8k and 9a-9j), antibacterial evaluation against the S. m...
Caulerpin as a potential antiviral drug against herpes simplex virus type 1
Macedo,Nathália Regina Porto Vieira; Ribeiro,Michele S.; Villaça,Roberto C.; Ferreira,Wilton; Pinto,Ana Maria; Teixeira,Valéria L.; Cirne-Santos,ClaudioAbout 80% of the human adult population is infected with HSV-1. Although there are many anti-HSV-1 drugs available (acyclovir, ganciclovir, valaciclovir, foscarnet), their continuous use promotes the selection of resistant strains, mainly in ACV patients. In addition to resistance, the drugs also have toxicity, particularly when administration is prolonged. The study of new molecules isolated from green algae w...
HIV-1 Reverse Transcriptase: a potential target for marine products
Miceli,Leonardo A.; Souza,Alessandra M. T. de; Rodrigues,Carlos R.; Paixão,Izabel C. N. P.; Teixeira,Valéria L.; Castro,Helena C.HIV-1 reverse transcriptase (HIV-1 RT) is a therapeutic target for the treatment of HIV-positive individuals or those already showing AIDS symptoms. In this perspective, the identification of new inhibitors for this enzyme is of great importance in view of the growing viral resistance to the existing treatments. This resistance has compromised the quality of life of those infected with multidrug-resistant strai...