6 documents found, page 1 of 1
Synthesis of xylitan derivatives and preliminary evaluation of in vitro trypano...
Elias, Paula Regina; Coelho, Gleicekelly Silva; Xavier, Viviane Flores; Sales Júnior, Policarpo Ademar; Romanha, Alvaro JoséA series of novel xylitan derivatives derived from xylitol were synthesized using operationally simple procedures. A xylitan acetonide was the key intermediate used to prepare benzoate, arylsulfonate esters and 1,2,3-triazole derivatives of xylitan. These compounds were evaluated for their in vitro anti-Trypanosoma cruzi activity against trypomastigote and amastigote forms of the parasite in T. cruzi-infected c...
Experimental and clinical treatment of Chagas disease : a review.
Sales Júnior, Policarpo Ademar; Molina, Israel; Murta, Silvane Maria Fonseca; Sánchez Montalvá, Adrián; Salvador, Fernando; Oliveira, Rodrigo Corrêa deChagas disease (CD) is caused by the protozoan parasite Trypanosoma cruzi that infects a broad range of triatomines and mammalian species, including man. It afflicts 8 million people in Latin America, and its incidence is increasing in nonendemic countries owing to rising international immigration and nonvectorial transmission routes such as blood donation. Since the 1960s, the only drugs available for the clin...
Synthesis of 3,5-Diarylisoxazole derivatives and evaluation of in vitro trypano...
Souza, Aline Aparecida Nunes de; Xavier, Viviane F.; Coelho, Gleicekelly Silva; Sales Júnior, Policarpo Ademar; Romanha, Alvaro JoséChagas disease is included in the neglected tropical diseases list and is endemic to 21 Latin American countries. The two drugs currently available for treating Chagas disease are nifurtimox and benznidazole and both result in many significant side effects. The study describes the synthesis and biological evaluation of 3,5-disubstituted isoxazoles. Isoxazoles were obtained by reaction of flavones and hydroxylam...
Accomplishing the genotype-specific serodiagnosis of single and dual Trypanosom...
Alessio, Glaucia Diniz; Araújo, Fernanda Fortes de; Sales Júnior, Policarpo Ademar; Gomes, Matheus de Souza; Amaral, Laurence Rodrigues doThe methods currently available for genotype-specific diagnosis of T. cruzi infection still present relevant limitations, especially to identify mixed infection. In the present investigation, we have evaluated the performance of Chagas-Flow ATE-IgG2a test for early and late differential diagnosis of single and dual genotype-specific T. cruzi infections. Serum samples from Swiss mice at early and late stages of ...
Performance of TcI/TcVI/TcII Chagas-Flow ATE-IgG2a for universal and genotype-s...
Alessio, Glaucia Diniz; Araújo, Fernanda Fortes de; Côrtes, Denise Fonseca; Sales Júnior, Policarpo Ademar; Lima, Daniela CristinaDistinct Trypanosoma cruzi genotypes have been considered relevant for patient management and therapeutic response of Chagas disease. However, typing strategies for genotype- specific serodiagnosis of Chagas disease are still unavailable and requires standardization for practical application. In this study, an innovative TcI/TcVI/TcII Chagas Flow ATE-IgG2a technique was developed with applicability for universa...
Innovations in diagnosis and post-therapeutic monitoring of Chagas disease : si...
Alessio, Glaucia Diniz; Côrtes, Denise Fonseca; Assis, Girley Francisco Machado de; Sales Júnior, Policarpo Ademar; Ferro, Eloisa Amália VieiraThis study developed a remarkable methodological innovation (FC-ATE) which enables simultaneous detection of antibodies specific to the three evolutive forms of Trypanosoma cruzi: live amastigote (AMA), live trypomastigote (TRYPO), and fixed epimastigote (EPI) using a differential fluorescence staining as low (AMA), intermediate (TRYPO), and high (EPI). An outstanding performance (100%) was observed in the disc...