132 documents found, page 1 of 14
Plasma-treated bacterial nanocellulose-lignin composites for biomedical applica...
Alves, Cátia; Melro, Liliana Sofia Silva Ferreira Pinto; Fernandes, Marta; Padrão, Jorge; Moldes, Diego; Serra, Sofia Cravino; Salgado, A. J.Bacterial nanocellulose (BC) as a bioimplant possesses several limitations, encompassing absence of bioactivity, and unsatisfactory mechanical properties. Envisaging antimicrobial activity, enhanced cytocompatibility and mitigation of the inflammatory response, surface characteristics such as hydrophilicity and rugosity were tailored. Different strategies comprising treatments with Kraft lignin (KL), glycerin (...
Bacterial nanocellulose as a versatile scaffold for biomedical applications: sy...
Melro, Liliana Sofia Silva Ferreira Pinto; Alves, Cátia Sofia Pereira; Fernandes, Marta Susana Machado; Rocha, Sofia Gomes; Mehravani, BehnazBacterial nanocellulose (BNC) consists of nanofibres of cellulose randomly entangled during their synthesis by particular bacterium cells during fermentation. Thus, it may be regarded as a unique three-dimensional of pure cellulose that is consolidated during the generation of the fibres by their microbiological factories. The metabolic synthesis and purification processes are approached, underscoring its poten...
Plasma-treated bacterial nanocellulose-lignin composites for neuralgia implants
Alves, Cátia Sofia Pereira; Melro, Liliana Sofia Silva Ferreira Pinto; Fernandes, Marta Susana Machado; Padrão, Jorge; Moldes, Diego[Excerpt] This research envisages the use of bacterial nanocellulose (BNC) as a biomaterial for implants to mitigate neuralgias, focusing on the material's inherent limitations. BNC is widely valued for its excellent mechanical properties, ease of modification, and non-anthropogenic degradability [1]. However, its absent electrical conductivity, insufficient antimicrobial activity, and weak interaction with neu...
Bacterial nanocellulose nanocomposites for medical applications
Zille, Andrea; Fernandes, Marta Susana Machado; Alves, Cátia Sofia Pereira; Melro, Liliana Sofia Silva Ferreira Pinto; Carvalho, Óscar Samuel Novais
Modification of nanocellulose
Fernandes, Marta Susana Machado; Alves, Cátia Sofia Pereira; Melro, Liliana Sofia Silva Ferreira Pinto; Fernandes, Rui Daniel Vilaça; Padrão, JorgeNanocellulose (NC) represents a pivotal material for the sustainable strategies of the future. NC comprises cellulose nanofibrils (CNFs), cellulose nanocrystals (CNCs), and bacterial nanocellulose (BNC), each exhibiting unique and exceptional physicochemical properties. These properties encompass high specific surface area, high tensile strength, lightweight, biodegradability, good barrier properties, and high ...
Neurodifferentiation and neuroprotection potential of mesenchymal stromal cell-...
Marques, Cláudia Raquel; Fuzeta, Miguel de Almeida; Cunha, Raquel Medina dos Santos; Pereira-Sousa, Joana; Silva, Deolinda; Campos, Jonas OliveiraParkinson’s disease (PD) is the second most common neurodegenerative disorder and is characterized by the degeneration of the dopamine (DA) neurons in the substantia nigra pars compacta, leading to a loss of DA in the basal ganglia. The presence of aggregates of alpha-synuclein (α-synuclein) is seen as the main contributor to the pathogenesis and progression of PD. Evidence suggests that the secretome of mesenc...
The assessment of bacterial nanocellulose functionalized with metal nanoparticles
Alves, Cátia Sofia Pereira; Melro, Liliana Sofia Silva Ferreira Pinto; Mehravani, Behnaz; Ribeiro, Ana Isabel Ferreira; Selvi, Burak; Bozaci, Erbu[Excerpt] Introduction Biocompatibility is one of the mandatory requirements of indwelling medical devices to avoid foreign body reactions and consequential surgical removal.
Enhanced neuronal differentiation by dynamic piezoelectric stimulation
Pinho, Tiffany S.; Silva, Deolinda; Ribeiro, Jorge Cibrão; Marote, Ana; Lima, Rui; Batista, Salete J.; Melo, Rita; Ribeiro, Clarisse Marta OliveiraAbstract Electroactive smart materials play an important role for tissue regenerative applications. Poly(vinylidene fluoride) (PVDF) is a specific subtype of piezoelectric electroactive material that generates electrical potential upon mechanical stimulation. This work focuses on the application of piezoelectric PVDF films for neural differentiation. Human neural precursor cells (hNPCs) are cultured on piezoele...
Revolutionizing disease modeling: the emergence of organoids in cellular systems
Pedrosa, Ana Rita Silva; Salgado, A. J.; Ferreira, Pedro Eduardo MendesCellular models have created opportunities to explore the characteristics of human diseases through well-established protocols, while avoiding the ethical restrictions associated with post-mortem studies and the costs associated with researching animal models. The capability of cell reprogramming, such as induced pluripotent stem cells (iPSCs) technology, solved the complications associated with human embryonic...
The central nervous system source modulates microglia function and morphology i...
Pinho, Andreia Filipa Gomes; Monteiro, Andreia Manuela Fernandes; Fernandes, Sara; de Sousa, Nídia; Salgado, A. J.; Silva, Nuno André MartinsThe regional heterogeneity of microglia was first described a century ago by Pio del Rio Hortega. Currently, new information on microglia heterogeneity throughout central nervous system (CNS) regions is being revealed by high-throughput techniques. It remains unclear whether these spatial specificities translate into different microglial behaviors in vitro. We cultured microglia isolated from the cortex and spi...