2 documents found, page 1 of 1
Cystlike Lesions as a Late Sequela of Radiotherapy in Pediatric Patients
Veiga, MGD; Fragata, I; Passos, J; Alves, M; Papoila, AL; Salgado, DBackground and purpose: The developing nervous system is particularly vulnerable to late adverse effects of cranial radiation therapy, such as leukoencephalopathy, microbleeds, and cavernomas. Cystlike lesions have been rarely described and characterized in the literature. We aimed to characterize cystlike lesions, their risk factors, and association with other late adverse effects. Materials and methods: Child...
BRAF V600E Mutation and 9p21: CDKN2A/B and MTAP Co-Deletions - Markers in the C...
Frazão, L; Martins, MC; Nunes, VM; Pimentel, J; Faria, C; Miguéns, J; Sagarribay, A; Matos, M; Salgado, D; Nunes, S; Mafra, M; Roque, LGenetic alterations in pediatric primary brain tumors can be used as diagnostic and prognostic markers and are the basis for the development of new target therapies that, ideally, would be associated with lower mortality and morbidity. This study evaluates the incidence and interplay of the presence of BRAF V600E mutation and chromosomal 9p21 deletions in a series of 100 pediatric gliomas, aiming to determine t...