6 documents found, page 1 of 1

Translation and Validation of the European Portuguese Version of the Quality of...

Introduction: The INF1-QoL questionnaire is an essential tool for assessing patients’ perceptions of their illness and its impact on their daily lives. This study aimed to obtain and validate the European Portuguese version of this questionnaire. Methods: The English version of INF1-QoL was translated using the “forward-backward” procedure. The questionnaire was administered to 78 adult patients with neurofibro...

Tongue Hyperpigmentation Associated with Temozolomide as a Single Agent: Case R...

Hyperpigmentation of the tongue has been associated with chemotherapy, specifically cytotoxic drugs, but the exact pathophysiological mechanism is still not well understood. We describe a 37-year-old black woman that presented with tongue hyperpigmentation one week after the initiation of chemotherapy with temozolomide as a single agent. No cases of tongue hyperpigmentation associated with temozolomide as a sin...

Evaluation and Treatment of Inoperable Plexiform Neurofibroma in Neurofibromato...

Selumetinib for plexiform neurofibromas in neurofibromatosis type 1: a single-i...

Background Plexiform neurofibromas (PN) are the most frequent tumors associated with Neurofibromatosis type 1 (NF-1). PN can cause significant complications, including pain, functional impairment, and disfigurement. There is no efficient medical treatment and, surgical resection of large PN is frequently infeasible. Selumetinib (AZD6244/ARRY-142886) is a mitogen-activated protein kinase enzyme (MEK1/2) inhibito...

Microbleeds and cavernomas after radiotherapy for paediatric primary brain tumours

Background: With the expected growth and aging of the population of primary central nervous system tumours (PCNST) survivors, attention to the radiation-induced late brain injury is fundamental. Late focal hemosiderin deposition (FHD) lesions, namely microbleeds and cavernomas, are among the presumable late cerebrovascular complications associated with radiotherapy for PCNST. Objective: To explore association b...

Cognitive function, cerebral microbleeds, radiotherapy, and bevacizumab in surv...

We read with great interest a recent paper published by Roddy et al showing a high (48.8%) 5-year cumulative incidence of cerebral microbleeds (CMB) and its association with cognitive dysfunction in a group with pediatric brain tumors who received cranial radiation therapy (CRT).1 We believe that exposing the association of CMB (or the associated underlying microvascular pathology) with cognitive impairment in ...