2 documents found, page 1 of 1
Bioengineered 3D living fibers as in vitro human tissue models of tendon physio...
Calejo, Isabel; Labrador-Rached, Claudia J.; Gomez-Florit, Manuel; Docheva, Denitsa; Reis, R. L.; Domingues, Rui Miguel Andrade; Gomes, Manuela E.Clinically relevant in vitro models of human tissue's health and disease are urgently needed for a better understanding of biological mechanisms essential for the development of novel therapies. Herein, physiological (healthy) and pathological (disease) tendon states are bioengineered by coupling the biological signaling of platelet lysate components with controlled 3D architectures of electrospun microfibers t...
Three-dimensional self-assembling nanofiber matrix rejuvenates aged/degenerativ...
Yin, Heyong; Strunz, Franziska; Yan, Zexing; Lu, Jiaju; Brochhausen, Christoph; Kiderlen, Stefanie; Clausen-Schaumann, Hauke; Wang, XiumeiThe poor healing capacity of tendons is known to worsen in the elderly. During tendon aging and degeneration, endogenous human tendon stem/progenitor cells (hTSPCs) experience profound pathological changes. Here, we explored a rejuvenation strategy for hTSPCs derived from aged/degenerated Achilles tendons (A-TSPCs) by providing three-dimensional (3D) nanofiber hydrogels and comparing them to young/healthy TSPCs...