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Polymorphisms in toll-like receptor genes and susceptibility to pulmonary asper...

Carvalho, Agostinho; Pasqualotto, A. C.; Pitzurra, L.; Romani, L; Denning, D. W.; Rodrigues, Fernando José dos Santos

Toll-like receptors (TLRs) are important components of innate immunity. We investigated the association between polymorphisms in the TLR2, TLR4, and TLR9 genes and susceptibility to noninvasive forms of pulmonary aspergillosis. A significant association was observed between allele G on Asp299Gly (TLR4) and chronic cavitary pulmonary aspergillosis (odds ratio [OR], 3.46; P =.003). Susceptibility to allergic bron...


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