Introduction: Optic nerve (ON) inclusion as the fifth location in dissemination in space (DIS) for the diagnosis of multiple sclerosis (MS) was proposed in 2016 by the Magnetic Resonance Imaging in Multiple Sclerosis Group. However, there was insufficient evidence to include this recommendation in the 2017 revision of McDonald criteria. Our objective was to investigate the effect of including ON involvement ass...
Introduction: Multiple sclerosis is a disease with a heterogeneous evolution. The early identification of secondary progressive multiple sclerosis is a clinical challenge, which would benefit from the definition of biomarkers and diagnostic tools applicable in the transition phase from relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis. We aimed to reach a Portuguese national con...