4 documents found, page 1 of 1
Early alveolar macrophage response and IL-1R-dependent T cell priming determine...
Lovey, Arianne; Verma, Sheetal; Kaipilyawar, Vaishnavi; Ribeiro-Rodrigues, Rodrigo; Husain, Seema; Palaci, Moises; Dietze, Reynaldo; Ma, ShuyiFunding Information: The work was funded by the National Institute of Allergy and Infectious Diseases, National Institutes of Health grants U19AI111276 and U01AI065663 to R.R.R., R.D., J.J.E. and P.S., and NIAID training grant T32AI125185 to A.L. The study sponsors were not involved in the study design, in the collection, analysis, and interpretation of data; in the writing of the manuscript; or in the decision...
Increase of cd4+cd25highfoxp3+ cells impairs in vitro human microbicidal activi...
Stringari, Lorenzzo Lyrio; Covre, Luciana Polaco; da Silva, Flávia Dias Coelho; de Oliveira, Vivian Leite; Campana, Maria Carolina; Hadad, David Jamil50204076]. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Publisher Copyright: © 2021 Stringari et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credit...
Mycobacterium tuberculosis progresses through two phases of latent infection in...
Colangeli, Roberto; Gupta, Aditi; Vinhas, Solange Alves; Chippada Venkata, Uma Deepthi; Kim, Soyeon; Grady, Courtney; Jones-López, Edward C.Little is known about the physiology of latent Mycobacterium tuberculosis infection. We studied the mutational rates of 24 index tuberculosis (TB) cases and their latently infected household contacts who developed active TB up to 5.25 years later, as an indication of bacterial physiological state and possible generation times during latent TB infection in humans. Here we report that the rate of new mutations in...
Transmission phenotype of mycobacterium tuberculosis strains is mechanistically...
Verma, Sheetal; Bhatt, Kamlesh; Lovey, Arianne; Ribeiro-Rodrigues, Rodrigo; Durbin, Joan; Jones-López, Edward C.; Palaci, Moises; Vinhas, Solange A.In a study of household contacts (HHC), households were categorized into High (HT) and Low (LT) transmission groups based on the proportion of HHC with a positive tuberculin skin test. The Mycobacterium tuberculosis (Mtb) strains from HT and LT index cases of the households were designated Mtb-HT and Mtb-LT, respectively. We found that C3HeB/FeJ mice infected with Mtb-LT strains exhibited significantly higher b...