4 documents found, page 1 of 1
Clinical value of cerebrospinal fluid neurofilament light chain in semantic dem...
Meeter, Lieke H. H.; Steketee, Rebecca M. E.; Salkovic, Dina; Vos, Maartje E.; Grossman, Murray; McMillan, Corey T.; Irwin, David J.; Boxer, Adam L.Background: Semantic dementia (SD) is a neurodegenerative disorder characterised by progressive language problems falling within the clinicopathological spectrum of frontotemporal lobar degeneration (FTLD). The development of disease-modifying agents may be facilitated by the relative clinical and pathological homogeneity of SD, but we need robust monitoring biomarkers to measure their efficacy. In different FT...
Algorithm for turning detection and analysis validated under home-like conditio...
Pham, Minh H.; Elshehabi, Morad; Haertner, Linda; Heger, Tanja; Hobert, Markus A.; Faber, Gert S.; Salkovic, Dina; Ferreira, Joaquim J; Berg, DanielaIntroduction: Aging and age-associated disorders such as Parkinson's disease (PD) are often associated with turning difficulties, which can lead to falls and fractures. Valid assessment of turning and turning deficits specifically in non-standardized environments may foster specific treatment and prevention of consequences. Methods: Relative orientation, obtained from 3D-accelerometer and 3D-gyroscope data of a...
Validation of a step detection algorithm during straight walking and turning in...
Pham, Minh H.; Elshehabi, Morad; Haertner, Linda; Del Din, Silvia; Srulijes, Karin; Heger, Tanja; Synofzik, Matthis; Hobert, Markus A.; Faber, Gert S.Introduction: Inertial measurement units (IMUs) positioned on various body locations allow detailed gait analysis even under unconstrained conditions. From a medical perspective, the assessment of vulnerable populations is of particular relevance, especially in the daily-life environment. Gait analysis algorithms need thorough validation, as many chronic diseases show specific and even unique gait patterns. The...
New methods for the assessment of Parkinson’s Disease (2005 to 2015): a systema...
Sánchez-Ferro, Alvaro; Elshehabi, Morad; Godinho, Catarina; Salkovic, Dina; Hobert, Markus A.; Domingos, Josefa; van Uem, Janet MT."BACKGROUND: The past decade has witnessed a highly dynamic and growing expansion of novel methods aimed at improving the assessment of Parkinson's disease with technology (NAM-PD) in laboratory, clinical, and home environments. However, the current state of NAM-PD regarding their maturity, feasibility, and usefulness in assessing the main PD features has not been systematically evaluated. METHODS: A systematic...