6 documents found, page 1 of 1
Faster cryptococcus melanization increases virulence in experimental and human ...
Sousa, Herdson Renney de; Oliveira Júnior, Getúlio Pereira de; Frazão, Stefânia de Oliveira; Gorgonha, Kaio César de Melo; Rosa, Camila PereiraCryptococcus spp. are human pathogens that cause 181,000 deaths per year. In this work, we systematically investigated the virulence attributes of Cryptococcus spp. clinical isolates and correlated them with patient data to better understand cryptococcosis. We collected 66 C. neoformans and 19 C. gattii clinical isolates and analyzed multiple virulence phenotypes and host–pathogen interaction outcomes. C. neofo...
A hidden battle in the dirt: Soil amoebae interactions with Paracoccidioides spp
Albuquerque, Patrícia; Nicola, André Moraes; Magnabosco, Diogo Almeida Gomes; da Silveira Derengowski, Lorena; Crisóstomo, Luana SoaresMade available in DSpace on 2020-12-12T01:42:02Z (GMT). No. of bitstreams: 0 Previous issue date: 2019-01-01; Paracoccidioides spp. are thermodimorphic fungi that cause a neglected tropical disease (paracoccidioidomycosis) that is endemic to Latin America. These fungi inhabit the soil, where they live as saprophytes with no need for a mammalian host to complete their life cycle. Despite this, they developed sop...
Comparative genomics of the major fungal agents of human and animal Sporotricho...
Teixeira, Marcus de Melo; Almeida, Luiz G. P. de; Barreira, Paula Kubitschek; Alves, Fernanda L.; Kioshima, Érika Seki; Abadio, Ana Karina RodriguesBackground: The fungal genus Sporothrix includes at least four human pathogenic species. One of these species, S. brasiliensis, is the causal agent of a major ongoing zoonotic outbreak of sporotrichosis in Brazil. Elsewhere, sapronoses are caused by S. schenckii and S. globosa. The major aims on this comparative genomic study are: 1) to explore the presence of virulence factors in S. schenckii and S. brasiliens...
Caracterização do módulo regulador do fator de transcrição Mlc1 de Cryptococcus...
Paes, Hugo CostaTese (doutorado)—Universidade de Brasília, Faculdade de Medicina, Programa de Pós-Graduação em Patologia Molecular, 2016.; Texto liberado parcialmente pelo autor. Conteúdo restrito: Apêndices.; Fatores de transcrição da família Gti1/Pac2 ocorrem exclusivamente em fungos e foram cooptados pela evolução para desempenhar papéis reguladores distintos de acordo com a espécie, papéis esses que vão do controle da tran...
Cell organisation, sulphur metabolism and ion transport-related genes are diffe...
Matos, Larissa Fernandes; Andrade, Rosângela Vieira de; Paes, Hugo Costa; Nicola, André Moraes; Carvalho, Maria José Albuquerque de; Fachin, Ana LúciaBackground Mycelium-to-yeast transition in the human host is essential for pathogenicity by the fungus Paracoccidioides brasiliensis and both cell types are therefore critical to the establishment of paracoccidioidomycosis (PCM), a systemic mycosis endemic to Latin America. The infected population is of about 10 million individuals, 2% of whom will eventually develop the disease. Previously, transcriptome analy...
Isolamento e caracterização funcional do fator de choque térmico (Hsf) do patóg...
Paes, Hugo CostaDissertação (mestrado)—Universidade de Brasília, Instituto de Ciências Biológicas, Departamento de Biologia Celular, 2009.; O presente trabalho foi o primeiro a caracterizar o fator de choque térmico (Hsf) em um fungo patogênico para humanos. O gene de Paracoccidioides brasiliensis isolado 01 (Pb01) teve sua seqüência determinada e analisada por ferramentas de bioinformática. Constatou-se que os domínios regula...